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Rate of HIV Seroconversion Among Seronegative Male Partners Living with HIV Positive Women in Addis Ababa, Ethiopia, 2019: A Retrospective Cohort Study

Authors Bantigen K, Kitaw L, Negeri H, Kebede M, Wassie A, Bishaw K, Tesema G

Received 9 September 2020

Accepted for publication 7 January 2021

Published 3 February 2021 Volume 2021:13 Pages 125—134

DOI https://doi.org/10.2147/HIV.S281281

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Professor Bassel Sawaya


Kerebih Bantigen,1 Leul Kitaw,1 Haweni Negeri,1 Mekonen Kebede,1 Addisu Wassie,2 Keralem Bishaw,3 Getaye Tesema4

1Nursing and Midwifery, Addis Ababa University, Addis Ababa, Ethiopia; 2Midwifery, Welayita Sodo University, Welayita Sodo, Ethiopia; 3Midwifery, Debre Markos University, Debre Markos, Ethiopia; 4Midwifery, Debreberhan University, Debreberhan, Ethiopia

Correspondence: Kerebih Bantigen
Nursing and Midwifery, Addis Ababa University, Addis Ababa, Ethiopia
Tel +251 991134859
Email kerebihab2015@gmial.com

Objective: This study aimed to assess rate of HIV seroconversion and predictors among seronegative male partners living with HIV-positive women in Addis Ababa, Ethiopia, 2019.
Methods: Institutional-based retrospective cohort was used to conduct the study. All eligible 227 sample medical records were used for the study. Kaplan–Meier analysis was used to estimate seroconversion time. Cox proportional-hazard regression was used to identify predictor variables.
Results: In this study, 227 seronegative male partners living with HIV-positive women were followed for 60 months retrospectively and 38 (16.7%) seroconversion was observed. The overall seroconversion rate was 6.4 (95%CI: 4.64– 8.76) per 100 person-year observation. Time of antiretroviral therapy (ART) initiation, CD4 level, condom use, and having history of pregnancy after being diagnosed as discordant were identified significant predictors of seroconversion.
Conclusion: The risk of HIV transmission from seropositive partner to seronegative partner in a discordant couple is poorly controlled. Seronegative partners in discordant a couple can be seropositive at any time with influence of predictors unless proper protective measures, counseling, and follow-up are given emphasis.

Keywords: HIV, discordant couple, seroconversion rate, Ethiopia

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