Back to Journals » International Journal of General Medicine » Volume 9

Quality-of-life indicators and falls due to vitamin D deficiency

Authors Cheema MR, Chaudhry A

Received 24 October 2014

Accepted for publication 13 January 2015

Published 22 February 2016 Volume 2016:9 Pages 21—25

DOI https://doi.org/10.2147/IJGM.S76360

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser


Muhammad Raza Cheema, Ahmad Yar Chaudhry

Department of Geriatrics, University Hospitals Coventry and Warwickshire, NHS Hospitals, Coventry, UK


Objective: To determine whether the number of falls and quality-of-life indicators relate to serum levels of vitamin D, parathyroid hormone (PTH), and calcium levels.
Design: A prospective study.
Participants: Patients being admitted with a fall with or without sustaining a fragility fracture post fall.
Measurements: Measured frequency of falling, SF-12 questionnaire, serum concentrations of 25-hydroxyvitamin D, calcium, and PTH levels before and after treatment with vitamin D supplementation.
Results: The mean age (N=38) of the cohort was 80.2±12. In all, 76.3% of the cohort had sustained a fragility fracture after the fall. The cohort was vitamin D deficient with the pretreatment mean value of 24.2±17 nmol/L and posttreatment mean value of 99±40 nmol/L with a statistically significant mean difference of 74.7 nmol/L (confidence interval [CI] 61.27–88.3), P=0.001. The levels of calcium and PTH were statistically significant after treatment with a mean difference of 0.16 (CI 0.1–0.2), P=0.001, and 3.7 (CI –4.8 to –2.5), P=0.001, respectively. After treatment, the mean difference of physical component score (PCS) and mental component score for the whole cohort was 2.9 (CI –0.69 to 6.6), P=0.10, and 1.05 (CI –2.6 to 4.7), P=0.56, respectively. However, a subgroup analysis for cohort aged ≤70 years provided a statistically significant effect on PCS with a mean difference of 8.9 (CI 1.3–16.4), P=0.03, but a statistically insignificant improvement in mental component score with a mean difference of 6.0 (CI –17 to –5.0), P=0.20. However, a statistically significant improvement in PCS SF-12 was observed in patients ≤70 years of age 2.9 (1.3–16.4), P=0.03. The mean number of falls for the whole cohort pre- and posttreatment was 1.11±0.92 vs 0.97±0.99 (P=0.68), respectively.
Conclusion: Patients who had fallen and sustained fragility fracture had lower serum 25-dihydroxyvitamin D and higher serum PTH levels. Our study demonstrates that there is no statistically significant improvement in the number of falls after treatment with vitamin D. Overall, vitamin D levels improved significantly, this is despite quality-of-life indicators showing a mean increase in PCS but not a statistically significant improvement. However, statistically significant improvement in PCS was observed in group aged ≤70 years after vitamin D supplementation.

Keywords: vitamin D, calcium, SF-12 questionnaire, parathyroid hormone

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]