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Pustular drug eruption due to Panax notoginseng saponins

Authors Yin ZQ, Ma LW, Xu JL, Xia JP, Luo D

Received 30 April 2014

Accepted for publication 17 May 2014

Published 16 July 2014 Volume 2014:8 Pages 957—961

DOI https://doi.org/10.2147/DDDT.S67015

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

ZhiQiang Yin,1,* LiWen Ma,1,* JiaLi Xu,2,* JiPing Xia,1 Dan Luo1

1Department of Dermatology, 2Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Jiangsu, People's Republic of China 

*These authors contributed equally to this work

Abstract: Panax notoginseng saponins (PNS) are a patented product in the People's Republic of China, and have extensive effects on the cardiovascular system. Here we report on four elderly patients (one male and three female) with drug eruption induced by PNS injection. All developed a sudden skin rash with pruritus from head to foot, and subsequently accepted hospitalization. In each case, PNS had been used for less than 1 week before appearance of the rash. No specific short-term medications or changes in diet or exposure to environmental factors immediately prior to appearance of the rash were identified. These four patients had some interesting features in common, ie, pustules, fever, and elevated circulating neutrophil counts, which required high-dose, long-term glucocorticoid therapy. To our knowledge, this is the first report of pustular drug eruption induced by PNS and provides a useful reference and warning for clinicians.

Keywords: pustule, drug eruption, acute generalized exanthematous pustulosis, Panax notoginseng saponins


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