Back to Journals » Neuropsychiatric Disease and Treatment » Volume 13

Psychosocial intervention for patients with type 2 diabetes mellitus and comorbid depression: a meta-analysis of randomized controlled trials

Authors Xie J, Deng W

Received 5 July 2016

Accepted for publication 8 September 2017

Published 24 October 2017 Volume 2017:13 Pages 2681—2690


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Professor Wai Kwong Tang

Jing Xie, Wuquan Deng

Department of Endocrinology and Nephrology, Chongqing Emergency Medical Center, the Fourth People’s Hospital of Chongqing, Chongqing, China

Background: The efficacy of psychosocial intervention has been proven in treatment of diabetic patients with depression in some studies. This meta-analysis was conducted to explore the efficacy as well as additional effects of this method during diabetic management in patients with type 2 diabetes mellitus (T2DM) and comorbid depression.
Methods: Electronic databases were searched from March 2000 to March 2017 for randomized controlled trials (RCTs) studying the effects of psychosocial intervention on T2DM patients with depression. There was no language limitation. Outcome measurements were symptoms of depression and anxiety, as well as glycemic control. A random effects model was conducted.
Results: In total, 31 RCTs composed of 2,616 patients were eligible for this analysis. The psychosocial intervention was effective for depression symptoms with pooled standardized mean difference (SMD) of –1.50 (95% CI =–1.83, –1.18) and anxiety symptoms with SMD of –1.18 (95% CI =–1.50, –0.85). Meanwhile, the additional effects indicated a better improvement of glycemic control, including the fasting blood-glucose with SMD of –0.93 (95% CI =–1.15, –0.71), 2-hour postprandial plasma glucose with SMD of –0.84 (95% CI =–1.13, –0.56), and hemoglobin A1c with SMD of –0.81 (95% CI =–1.10, –0.53).
Conclusion: These results demonstrate that the psychosocial intervention is very effective in treating T2DM patients with depression.

Keywords: psychosocial intervention, type 2 diabetes mellitus, depression, meta-analysis

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]