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Psoriasis and uveitis: links and risks

Authors Fotiadou C, Lazaridou E

Received 25 February 2019

Accepted for publication 1 August 2019

Published 28 August 2019 Volume 2019:9 Pages 91—96

DOI https://doi.org/10.2147/PTT.S179182

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Professor Uwe Wollina


Christina Fotiadou, Elizabeth Lazaridou

Second Department of Dermatology-Venereology, Aristotle University Medical School, Thessaloniki, Greece

Correspondence: Christina Fotiadou
Second Department of Dermatology-Venereology, Aristotle University Medical School, 1 Chrysochoou Street 1221, Larisa, Greece
Tel +30 697 728 0180
Email christinafotiadou@yahoo.com

Abstract: Uveitis, an inflammatory disorder of the mid-portion of the eye, is considered a relatively rare but very serious ocular complication of psoriasis. Data on the specific characteristics of uveitis in the background of psoriasis are extremely limited. The presence of uveitis in the context of psoriasis has been estimated to occur in 7–20% of the psoriasis cases. This incidence tends to be higher in patients suffering from psoriasis and psoriatic arthritis (PsA) or PSA alone. Psoriatic uveitis is usually bilateral, chronic, and severe. In term of pathogenesis, both psoriasis and uveitis are considered as paradigms of T-helper 1/T-helper 17 (Th1/Th17) inflammatory reactions. Certain cytokines such as tumor necrosis factor-α (TNF- α), Interleukin-17 (IL-17), IL-23, and IL-6 play a significant role in the pathogenesis of both psoriasis and uveitis. As uveitis shares common pathogenetic mechanisms with psoriasis in certain circumstances, both diseases may benefit from the same targeted biologic therapies. Undiagnosed and under-treated cases of psoriatic uveitis may cause significant morbidity and even vision loss. Larger prospective studies are needed in order to further investigate the association between these two entities.

Keywords: psoriasis, uveitis, pathogenetic link

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