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Protective effects of L-glutamine against toxicity of deltamethrin in the cerebral tissue

Authors Varol S, Ozdemir HH, Cevik MU, Altun Y, Ibiloğlu I, Ekinci A, Okan İbiloğlu A, Balduz M, Arslan D, Tekin R, Aktar F, Aluçlu MU

Received 11 January 2016

Accepted for publication 15 February 2016

Published 21 April 2016 Volume 2016:12 Pages 1005—1011

DOI https://doi.org/10.2147/NDT.S104011

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Lucy Goodman

Peer reviewer comments 4

Editor who approved publication: Dr Roger Pinder


Sefer Varol, Hasan Hüseyin Özdemir, Mehmet Uğur Çevik, Yaşar Altun, Ibrahim Ibiloğlu, Aysun Ekinci, Aslıhan Okan Ibiloğlu, Metin Balduz, Demet Arslan, Recep Tekin, Fesih Aktar, Mehmet Ufuk Aluçlu

Department of Neurology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey

Background: Deltamethrin (DLM) is a broad-spectrum synthetic dibromo-pyrethroid pesticide that is widely used for agricultural and veterinary purposes. However, human exposure to the pesticide leads to neurotoxicity. Glutamine is one of the principal, free intracellular amino acids and may also be an antioxidant. This study was undertaken in order to examine the neuroprotective and antioxidant potential of L-glutamine against DLM toxicity in female Wistar albino rats.
Materials and methods: The rats were divided into the following groups (n=10): Group I: control (distilled water; 10 mL/kg, po one dose), Group II: L-glutamine (1.5 g/kg, po one dose), Group III: DLM (35 mg/kg, po one dose), and Group IV: DLM (35 mg/kg, po one dose) and L-glutamine (1.5 g/kg, po one dose after 4 hours). Total oxidant status (TOS), total antioxidant status (TAS), tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 levels and apoptosis were evaluated in brain tissue.
Results: DLM-treated animals had a significant increase in brain biochemical parameters, as well as TOS and TAS. Furthermore, the histopathological examination showed neuronal cell degeneration in the cerebral tissue. L-Glutamine treatment decreased the elevated brain levels of TOS and neuronal cell degeneration. There was no difference in tumor necrosis factor-α, IL-1β, and IL-6 levels between the groups.
Conclusion: L-Glutamine may reduce the toxic effects of DLM in the cerebral tissue through antioxidant properties.

Keywords: deltamethrin, L-glutamine, rat

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