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Protective Effects of Curcumin and its Nano-Phytosome on Carrageenan-Induced Inflammation in Mice Model: Behavioral and Biochemical Responses

Authors Baradaran S, Hajizadeh Moghaddam A, Khanjani Jelodar S, Moradi-kor N

Received 4 October 2019

Accepted for publication 10 December 2019

Published 21 January 2020 Volume 2020:13 Pages 45—51

DOI https://doi.org/10.2147/JIR.S232462

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Ning Quan


Saeideh Baradaran, 1 Akbar Hajizadeh Moghaddam, 1 Sedigheh Khanjani Jelodar, 1 Nasroallah Moradi-kor 2

1Department of Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran; 2Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran

Correspondence: Nasroallah Moradi-kor
Research Center of Physiology, Semnan University of Medical Sciences, Damghan Road, P.O. Box 35195-163, Semnan, Iran
Email moradikor.nasroallah@yahoo.com
Akbar Hajizadeh Moghaddam
Department of Biology, Faculty of Basic Sciences, University of Mazandaran, P.O. Box 57416-13534, Babolsar, Iran
Email a.hajizadeh@umz.ac.ir

Background and purpose: Natural compounds are used for prevention of inflammation. Curcumin has antioxidant and anti-inflammatory properties, and loading it into nano-phytosomes may improve its efficiency. The present study investigates the effects of curcumin and its nano-phytosome on behavioral and biochemical responses in carrageenan-induced inflammation in the mice model.
Methods: The mice were divided into six groups and received oral administration of curcumin or its nano-phytosome at a dose of 15 mg/kg for seven days before the administration of carrageenan. Acute inflammation in the mice was induced by administration of carrageenan (1%) into the subplantar region of the left paw. Antioxidant activity and behavioral responses were then evaluated.
Results: The results showed that the serum concentrations of antioxidant enzymes were significantly higher in the sal+sal group compared to the cara+sal group (P< 0.05). Using nanophytosome, separately and in combination with indomethacin, increased the levels of antioxidant enzymes compared to the cara+sal group (P< 0.05). Latency was significantly lower in the cara+sal group compared to the cara+sal group (P< 0.05), but it was considerably higher in other groups, especially in the cara+nano.ph.cur+indo group (P< 0.05).
Conclusion: It can be stated that the nano-phytosome of curcumin could improve antioxidant and behavioral responses in inflamed mice.

Keywords: antioxidant activity, inflammation, mice model, nano-phytosome

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