Prognostic value of the C-reactive protein/albumin ratio in patients with laryngeal squamous cell carcinoma
Authors Yu S, Zhou Z, Cai Q, Liang F, Han P, Chen R, Huang X
Received 22 November 2016
Accepted for publication 18 January 2017
Published 15 February 2017 Volume 2017:10 Pages 879—884
Checked for plagiarism Yes
Review by Single-blind
Peer reviewer comments 2
Editor who approved publication: Dr Carlos E Vigil
Shi-tong Yu,1,2,* Zhiwei Zhou,1,2,* Qian Cai,1,2 Faya Liang,1,2 Ping Han,1,2 Renhui Chen,1,2 Xiao-ming Huang1,2
1Department of Otolaryngology, Head and Neck Surgery, 2Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China
*These authors contributed equally to this work
Purpose: The present study was designed to retrospectively evaluate the prognostic value of the C-reactive protein/albumin (CRP/ALB) ratio in laryngeal squamous cell carcinoma (LSCC).
Methods: One hundred and twenty-nine newly diagnosed LSCC patients admitted between May 2006 and October 2011 were retrospectively reviewed. Their serum CRP and ALB were quantified preoperatively. The relationship between the CRP/ALB ratio and the clinicopathologic features was analyzed. Receiver operating characteristic curve was used to calculate the prognostic value of the CRP/ALB ratio. Then, the Cox proportional hazards model was used in univariate and multivariate analyses to identify significant prognostic factors associated with disease-free survival and overall survival.
Results: The cutoff value for CRP/ALB ratio was 0.047. An elevated CRP/ALB ratio was significantly associated with nodal metastasis, late disease stage, and recurrence. Also, high values of CRP/ALB ratio were significant predictors for poor overall survival and disease-free survival on multivariate analysis.
Conclusion: Pretreatment CRP/ALB ratio may be a significant prognostic marker in LSCC.
Keywords: C-reactive protein/albumin ratio, laryngeal squamous cell carcinoma, prognosis, survival
This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.Download Article [PDF] View Full Text [HTML][Machine readable]