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Prognostic value of CD44v6 expression in breast cancer: a meta-analysis

Authors Qiao GL, Song LN, Deng ZF, Chen Y, Ma LJ

Received 4 November 2017

Accepted for publication 23 June 2018

Published 4 September 2018 Volume 2018:11 Pages 5451—5457

DOI https://doi.org/10.2147/OTT.S156101

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Ms Justinn Cochran

Peer reviewer comments 3

Editor who approved publication: Dr Samir Farghaly


Guang-Lei Qiao, Li-Na Song, Zhou-feng Deng, Ying Chen, Li-Jun Ma

Department of Oncology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

Purpose: The prognostic value and clinical significance of CD44 variant isoform v6 (CD44v6) in breast cancer remains controversial. Our study aimed to generalize the correlation between CD44v6 expression and clinicopathological features and prognosis in breast cancer by using a meta-analysis.
Methods: We performed a comprehensive search of relevant literature from PubMed, Cochrane Database, and EMBASE database that were published before January 2018. The pooled ORs and HRs with 95% CIs were used to estimate the effects.
Results: Thirteen articles comprising 1,458 patients were included for analysis. The results revealed that CD44v6 expression was associated with histological grade (overall: OR=1.56, 95% CI [1.06, 2.29], P=0.023; Asian: OR=1.78, 95% CI [1.12, 2.85], P=0.016) and lymph node metastasis (overall: OR=1.96, 95% CI [1.01, 3.78], P=0.046; Asian: OR=2.11, 95% CI [1.00, 4.44], P=0.049). CD44v6 expression was significantly associated with poor prognosis in patients with breast cancer (overall survival: overall: HR=1.55, 95% CI [1.09, 2.22], P=0.015; Asian: HR=2.22, 95% CI [1.34, 3.68], P=0.002).
Conclusion: Our meta-analysis demonstrates that CD44v6 is significantly associated with poor prognosis, histological grade, and lymph node metastasis in breast cancer patients, especially among Asian patients.

Keywords: CD44v6, breast cancer, prognosis, metastasis, meta-analysis

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