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Prognostic value of aspartate aminotransferase to platelet ratio index as a noninvasive biomarker in patients with hepatocellular carcinoma: a meta-analysis

Authors Zhang Y, Zhang X

Received 14 May 2018

Accepted for publication 18 June 2018

Published 29 August 2018 Volume 2018:10 Pages 3023—3032

DOI https://doi.org/10.2147/CMAR.S174095

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Ms Justinn Cochran

Peer reviewer comments 3

Editor who approved publication: Dr Kenan Onel


Yi Zhang, Xu Zhang

Department of General Surgery, the First People’s Hospital of Neijiang, Neijiang, Sichuan Province, China

Background: The aspartate aminotransferase-to-platelet ratio index (APRI) has been correlated with clinical outcome in patients with hepatocellular carcinoma (HCC), but controversial results were obtained with previous studies. This study was aimed to evaluate the prognostic value of the APRI in patients with HCC.
Materials and methods: A literature survey was conducted by searching PubMed, Web of Science, Cochrane library, Embase, Wanfang, and National Knowledge Infrastructure for publications released prior to March 1, 2018. Pooled hazard ratios (HRs) with 95% CIs were calculated to assess the association between the APRI and HCC prognosis using Stata SE 12.0 software.
Results: Analysis was performed on a total of 15 articles that included 5,051 patients. The pooled results showed that APRI was significantly associated with overall survival for patients with HCC (HR =1.62, 95% CI: 1.23–2.01). Furthermore, HCC patients with higher APRI were at significantly greater risk of short recurrence-free survival (HR =1.83, 95% CI: 1.48–2.18) and poor disease-free survival (HR =1.46, 95% CI: 1.26–1.66).
Conclusions: APRI could serve as a promising and noninvasive marker for predicting HCC prognosis.

Keywords: aspartate aminotransferase-to-platelet ratio index, hepatocellular carcinoma, prognosis, meta-analysis

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