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Prognostic value and clinical significance of long noncoding RNA CASC2 in human malignancies: a meta-analysis

Authors Cai J, Zuo X, Chen Z, Zhao W, Zhu Y, Zhang Z, Ye X

Received 3 January 2018

Accepted for publication 22 March 2018

Published 31 May 2018 Volume 2018:10 Pages 1403—1412

DOI https://doi.org/10.2147/CMAR.S161373

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Professor Lu-Zhe Sun


Juan Cai,1,* Xueliang Zuo,2,* Zhiqiang Chen,3,4,* Wenying Zhao,1 Yiping Zhu,1 Zhengxiang Zhang,1 Xiaobing Ye1

1Department of Oncology, The First Affiliated Hospital, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui, China; 2Department of Gastrointestinal Surgery, The First Affiliated Hospital, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui, China; 3Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China; 4Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, Nanjing, Jiangsu, China

*These authors contributed equally to this work

Purpose: This meta-analysis aimed to assess the prognostic value of long noncoding RNA cancer susceptibility candidate 2 (CASC2) in human tumors.
Materials and methods: We searched the available databases up to December 2017. Pooled hazard ratios (HRs) and the corresponding 95% confidence intervals (CIs) were used to examine the prognostic impact of CASC2 on overall survival (OS) in patients diagnosed with malignancies.
Results: A total of eight studies with 663 cancer patients were enrolled. Our results showed that high CASC2 expression level was associated with a favorable OS (HR=0.437, 95% CI: 0.345–0.554). The significant results were not altered by stratified analysis according to cancer type, sample size, follow-up months, and HR estimation method. A significant association of glioma tumor stage with CASC2 expression was detected (III–IV vs I–II: odds ratio=2.126, 95% CI: 1.032–4.378). CASC2 could be used as an independent prognostic factor for OS (HR=0.450, 95% CI: 0.336–0.602). Sensitivity analysis showed that no single study changed the pooled results significantly. Begg’s funnel plot and Egger’s test showed that no publication bias was detected.
Conclusion:
High expression level of CASC2 is associated with favorable survival outcome for cancer patients, and CASC2 could be used as a prognostic predictor for cancers.

Keywords: CASC2, long noncoding RNA, prognosis, meta-analysis

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