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Prognostic significance of microRNA-100 in solid tumors: an updated meta-analysis

Authors Wang J, Yu M, Guan S, Zhang G, Wang J, Cheng Y

Received 20 September 2016

Accepted for publication 5 November 2016

Published 23 January 2017 Volume 2017:10 Pages 493—502

DOI https://doi.org/10.2147/OTT.S122774

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Ashok Kumar Pandurangan

Peer reviewer comments 2

Editor who approved publication: Dr Chiung-Kuei Huang

Jiangfeng Wang,1 Miao Yu,2 Shanghui Guan,1 Guangyu Zhang,1 Jianbo Wang,1 Yufeng Cheng1

1Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, People’s Republic of China; 2School of Medicine, University of Washington, Seattle, WA, USA

Objective: The aim of this study was to identify prognostic significance of microRNA-100 (miR-100) in solid tumor.
Methods: Literature search was conducted in databases such as PubMed, Embase, and Web of Science, using the following words “(microRNA-100 OR miR-100 OR mir100) AND (tumor OR neoplasm OR cancer OR carcinoma OR malignancy).” The search was updated up until July 10, 2016. Newcastle–Ottawa scale was used to evaluate the quality of studies. Pooled hazard ratio (HR) with 95% confidence interval (CI) for patients’ survival was calculated by using a fixed-effects or a random-effects model on the basis of heterogeneity. Subgroup analysis, sensitive analysis, and meta-regression were used to investigate the sources of heterogeneity. Publication bias was evaluated by using Begg’s and Egger’s tests.
Results:
A total of 16 articles with 1,501 patients were included in the present meta-analysis. It was demonstrated that a lower expression of miR-100 plays a negative role in the overall survival (OS) of patients with solid tumor (HR =1.92; 95% CI =1.25–2.94). In addition, the association between miR-100 and prognosis was also revealed in the following subgroups: non-small-cell lung cancer (NSCLC; HR =2.46; 95% CI =1.98–3.06), epithelial ovarian cancer (EOC; HR =2.29, 95% CI =1.72–3.04), and bladder cancer (BC; HR =4.14, 95% CI =1.85–9.27).
Conclusion:
This meta-analysis indicates that lower expression of miR-100 is related to poorer OS in patients with solid tumor, especially in those with NSCLC, EOC, and BC. MiR-100 is a promising prognosis predictor and may be a potential target for therapy in the future.

Keywords: microRNA-100, prognosis, meta-analysis

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