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Prognostic significance and biological function of Lamina-associated polypeptide 2 in non-small-cell lung cancer

Authors Liu C, Yu H, Shen X, Qiao J, Wu X, Chang J, Zhu X, Wang J, Shen X

Received 11 July 2018

Accepted for publication 26 April 2019

Published 16 May 2019 Volume 2019:12 Pages 3817—3827

DOI https://doi.org/10.2147/OTT.S179870

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr XuYu Yang


Chang Liu,1,2,* Hui Yu,1,2,* Xuxia Shen,2,3 Jie Qiao,1,2 Xianghua Wu,1,2 Jianhua Chang,1,2 Xunxia Zhu,4 Jialei Wang,1,2 Xiaoyong Shen4


1Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, People’s Republic of China; 2Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, People’s Republic of China; 3Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, People’s Republic of China; 4Department of Thoracic Surgery, The Affiliated Huadong Hospital of Fudan University, Shanghai 200040, People’s Republic of China

*These authors contributed equally to this work

Purpose:
Lamina-associated polypeptide 2 (LAP2; encoded by TMPO), is a nuclear protein that may affect chromatin regulation and gene expression through dynamically binding to nuclear lamin. TMPO (LAP2) plays dual roles of either suppressing or promoting proliferation of cells, depending on the status of the cell. It has been reported that TMPO is up-regulated in various cancer types. However, its function in lung cancer has not been studied yet.
Materials and methods: A series of clinical microarray datasets for lung cancer were investigated to demonstrate the expression of TMPO. The transcription of TMPO gene in human lung cancer was analyzed using Oncomine platform (www.oncomine.org) according to the standardized procedures described previously. Four separate datasets (Hou Lung, Okayama Lung, Beer Lung, and Garber Lung) were analyzed.
Results: Here, we show that TMPO is over-expressed in lung cancer tissues, and that a high level of TMPO indicates a poor prognosis in lung cancer patients. Knockdown of TMPO in lung cancer cells inhibits cell proliferation and induces apoptosis. Also, down-regulation of TMPO leads to an impaired metastatic ability of tumor cells. A nude mice tumor model show that knockdown of TMPO suppresses tumor formation in vivo.
Conclusion: Collectively, this study suggests TMPO as an oncogene and a novel prognostic gene in lung cancer.

Keywords: TMPO, LAP2, non-small-cell lung cancer, prognostic factor, oncogene

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