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Prognosis of patients with primary malignant main stem bronchial tumors: 7,418 cases based on the SEER database

Authors Ma K, Sun F, Yang X, Wang S, Wang L, Jin Y, Shi Y, Jiang W, Zhan C, Wang Q

Received 29 May 2017

Accepted for publication 28 November 2017

Published 22 December 2017 Volume 2018:11 Pages 83—95

DOI https://doi.org/10.2147/OTT.S142847

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Dr XuYu Yang


Ke Ma,* Fenghao Sun,* Xiaodong Yang, Shuai Wang, Lin Wang, Yulin Jin, Yu Shi, Wei Jiang, Cheng Zhan, Qun Wang

Department of Thoracic Surgery, Zhongshan Hospital of Fudan University, Shanghai, People’s Republic of China

*These authors contributed equally to this work

Background: The aim of this study was to identify risk factors for patients with malignant main stem bronchial tumors (MBTs) and to develop a nomogram for predicting prognosis in those patients using data from the Surveillance, Epidemiology, and End Results (SEER) database.
Method: A process was used for case screening from the SEER database. The effect of prognostic factors on survival was evaluated using the Kaplan–Meier method and log-rank test, a competing risk model, and the Cox proportional hazards regression model. A nomogram was established for predicting 1-, 3-, and 5-year overall survival (OS) in patients with MBTs.
Results: A total of 7,418 cases were included in this study. Age, gender, pathologic grade, histologic type, tumor size, involvement of lymph nodes, tumor extension, chemotherapy, and surgery were identified as independent risk factors by univariate and multivariate analyses. A nomogram was established based on the results of the Cox model, which was validated by a C-index of 0.672 (95% CI, 0.664–0.680), and a group of calibration plots.
Conclusion: Age, gender, pathologic grade, histologic type, tumor size, involvement of lymph nodes, tumor extension, chemotherapy, and surgery were independent risk factors for OS of patients with MBTs. A nomogram was formulated to predict 1-, 3-, and 5-year OS in patients with MBTs based on individual clinical characteristics.

Keywords: malignant main stem bronchial tumor, nomogram, prognosis, risk factors

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