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Profile of tildrakizumab-asmn in the treatment of moderate-to-severe plaque psoriasis: evidence to date

Authors Beck KM, Sanchez IM, Yang EJ, Liao W

Received 26 April 2018

Accepted for publication 4 July 2018

Published 29 August 2018 Volume 2018:8 Pages 49—58

DOI https://doi.org/10.2147/PTT.S146640

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Ms Justinn Cochran

Peer reviewer comments 2

Editor who approved publication: Professor Uwe Wollina


Kristen M Beck, Isabelle M Sanchez, Eric J Yang, Wilson Liao

Department of Dermatology, University of California San Francisco, San Francisco, CA, USA

Abstract: Plaque psoriasis is an immune-mediated skin disease that affects roughly 3% of adults in the United States. Advances over the past 20 years in understanding the immune-mediated pathophysiology of psoriasis have led to the development of targeted biologic therapies for this condition. Currently, biologic medications approved for the treatment of plaque psoriasis include tumor necrosis factor α inhibitors, interleukin (IL)-17 or IL-17 receptor inhibitors, IL-12/23 inhibitors, and IL-23 inhibitors. Tildrakizumab-asmn is a monoclonal antibody that targets the p19 subunit of IL-23 and is approved for use in adult patients with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy. This article reviews the current pharmacologic, efficacy, and safety data on tildrakizumab-asmn.

Keywords: tildrakizumab, IL-23, IL-23p19, biologics, psoriasis

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