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Profile of reslizumab in eosinophilic disease and its potential in the treatment of poorly controlled eosinophilic asthma

Authors Walsh G

Received 23 November 2012

Accepted for publication 14 December 2012

Published 9 January 2013 Volume 2013:7 Pages 7—11

DOI https://doi.org/10.2147/BTT.S30133

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3


Garry M Walsh

Division of Applied Medicine, School of Medicine and Dentistry, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK

Abstract: Eosinophils are important proinflammatory cells that make a major contribution to the inflammation seen in allergic diseases including asthma. Interleukin-5 is central to eosinophil maturation, release from the bone marrow, and subsequent accumulation, activation, and persistence in the tissues. Reslizumab (Cinquil™) is a humanized monoclonal antibody with potent interleukin-5 neutralizing effects, which represents a potential treatment for poorly controlled eosinophilic asthma. This review will consider the current status of the clinical development of reslizumab for asthma and in other inflammatory diseases with a marked eosinophilic component.

Keywords: IL-5, asthma, eosinophil

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