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Profile of minocycline and its potential in the treatment of schizophrenia

Authors Zhang L, Zhao J

Received 17 March 2014

Accepted for publication 22 April 2014

Published 17 June 2014 Volume 2014:10 Pages 1103—1111

DOI https://doi.org/10.2147/NDT.S64236

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Lulu Zhang,1,2 Jingping Zhao1

1Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan, 2Department of Psychology, Guangzhou First People’s Hospital, Guangzhou, Guangdong, People’s Republic of China

Abstract: Accumulating evidence suggests that neuroinflammation affecting microglia plays an important role in the etiology of schizophrenia, and appropriate control of microglial activation may be a promising therapeutic strategy for schizophrenia. Minocycline, a second-generation tetracycline that inhibits microglial activation, has been shown to have a neuroprotective effect in various models of neurodegenerative disease, including anti-inflammatory, antioxidant, and antiapoptotic properties, and an ability to modulate glutamate-induced excitotoxicity. Given that these mechanisms overlap with neuropathologic pathways, minocycline may have a potential role in the adjuvant treatment of schizophrenia, and improve its negative symptoms. Here, we review the relevant studies of minocycline, ranging from preclinical research to human clinical trials.

Keywords: schizophrenia, minocycline, microglia, neuroinflammation

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