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Profile of inotuzumab ozogamicin and its potential in the treatment of acute lymphoblastic leukemia

Authors Thomas X

Received 25 November 2013

Accepted for publication 7 January 2014

Published 17 April 2014 Volume 2014:4 Pages 1—8

DOI https://doi.org/10.2147/BLCTT.S49048

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4


Xavier Thomas

Hospices Civils de Lyon, Hematology, Lyon-Sud Hospital, Pavillon Marcel Bérard, France

Abstract: Monoclonal antibodies are likely to make a considerable contribution in the treatment of acute lymphoblastic leukemia (ALL). High expression of CD22 antigen is found on the surface of leukemia cells in ALL. Inotuzumab ozogamicin, a CD22 monoclonal antibody conjugated to calicheamicin, which has shown efficacy in patients with lymphomas, has also shown encouraging activity in relapsed or refractory ALL with a high morphologic and molecular response rate. This article summarizes the current approaches to treating ALL with inotuzumab ozogamicin, based on available data from the literature.

Keywords: monoclonal antibody, inotuzumab ozogamicin, CMC-544, acute lymphoblastic leukemia, targeted therapy


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