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Profile of abemaciclib and its potential in the treatment of breast cancer

Authors Martin JM, Goldstein LJ

Received 11 April 2018

Accepted for publication 23 June 2018

Published 29 August 2018 Volume 2018:11 Pages 5253—5259

DOI https://doi.org/10.2147/OTT.S149245

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Andrew Yee

Peer reviewer comments 2

Editor who approved publication: Dr Samir Farghaly


James M Martin,1 Lori J Goldstein2

1Department of Medicine, Section of Hematology/Oncology, Temple University Hospital, Philadelphia, PA, USA; 2Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA

Abstract: Hormone-receptor-positive breast cancer is the most common subtype of breast cancer among patients with both early-stage and metastatic disease. Recent advances in the understanding of its pathophysiology have led to the discovery and utilization of targeted inhibitors to cyclin-dependent kinases 4 and 6 (CDK4/6). There are currently three available CDK4/6 inhibitors available for use in USA: palbociclib, ribociclib, and abemaciclib. Their oral administration and tolerable toxicities make this class of agents appealing to both patients and health care providers. Abemaciclib, the most recently approved CDK4/6 inhibitor, has unique pharmacologic properties and potential toxicities. This review highlights the current understanding of abemaciclib and discusses its current and future roles in the treatment of breast cancer.

Keywords: abemaciclib, cyclin D1, breast cancer, CDK4/6

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