Back to Journals » OncoTargets and Therapy » Volume 9

Primary adenoid cystic carcinoma of the trachea with thyroid invasion: a case report and literature review

Authors Qi D, Feng L, Li J, Liu B, Zhang Q

Received 11 May 2016

Accepted for publication 9 September 2016

Published 13 October 2016 Volume 2016:9 Pages 6291—6296


Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Ram Prasad

Peer reviewer comments 4

Editor who approved publication: Professor Jianmin Xu

Dianjun Qi,1 Liang Feng,2 Jian Li,3 Bing Liu,4 Qingfu Zhang5

1Department of General Practice, 2Department of Breast Surgery, 3Department of Radiology, 4Department of Anorectal Surgery, The First Affiliated Hospital of China Medical University, 5Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences of China Medical University, Shenyang, People’s Republic of China

Abstract: Primary adenoid cystic carcinoma (ACC) of the trachea with thyroid invasion is very rare. In this report, we present a 46-year-old man with primary ACC of the trachea with thyroid invasion. ACC invasion of the thyroid is very rare and is easily misdiagnosed. The patient sought consultation due to a 6-month history of dysphagia and associated dyspnea. A contrast-enhanced computed tomography scan obtained at the time of admission revealed bilateral thyroid masses and tracheal wall thickening. The thyroid masses were fused to the trachea and the esophagus without discernible borders, intraoperatively. Frozen pathology suggested poorly differentiated cancer, and a bilateral partial thyroidectomy was performed. Postoperative pathology revealed primary tracheal ACC with thyroid invasion. The patient died 1 month after surgery. We have also summarized the literature on the clinical presentation, diagnosis, and treatment of thyroid-invasive ACC.

Keywords: trachea, adenoid cystic carcinoma, thyroid

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]