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Prevalence of periprosthetic osteolysis after total hip replacement in patients with rheumatic diseases

Authors Perez Alamino R, Casellini C, Banos A, Schneeberger E, Gagliardi S, Maldonado Cocco J, Citera G

Received 13 March 2012

Accepted for publication 28 March 2012

Published 6 June 2012 Volume 2012:4 Pages 57—62

DOI https://doi.org/10.2147/OARRR.S31736

Review by Single anonymous peer review

Peer reviewer comments 2


Rodolfo Perez Alamino, Carolina Casellini, Andrea Banos, Emilce Edith Schneeberger, Susana Alicia Gagliardi, José Antonio Maldonado Cocco, Gustavo Citera
Section of Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina

Abstract: Periprosthetic osteolysis (PO) is a frequent complication in patients with joint implants. There are no data regarding the prevalence of PO in patients with rheumatoid arthritis (RA), juvenile chronic arthritis (JCA), ankylosing spondylitis (AS), and osteoarthritis (OA).
Objectives: To evaluate the prevalence of PO in patients with RA, JCA, AS, and OA, who have undergone total hip replacement (THR), and to identify factors associated with its development.
Methods: The study included patients diagnosed with RA (ACR 1987), AS (modified New York criteria), JCA (European 1977 criteria), and osteoarthritis (OA) (ACR 1990 criteria) with unilateral or bilateral THR. Demographic, clinical, and therapeutic data were collected. Panoramic pelvic plain radiographs were performed, to determine the presence of PO at acetabular and femoral levels. Images were read by two independent observers.
Results: One hundred twenty-two hip prostheses were analyzed (74 cemented, 30 cementless, and 18 hybrids). The average time from prosthesis implantation to pelvic radiograph was comparable among groups. PO was observed in 72 hips (59%). In 55% of cases, PO was detected on the femoral component, with a lower prevalence in RA (53%) vs AS (64.7%) and JCA (76.5%). Acetabular PO was more frequent in JCA patients (58.8%), compared with RA (11.6%) and OA (28.5%) patients (P = 0.0001 and P = 0.06, respectively). There was no significant association between the presence of PO and clinical, functional, or therapeutic features.
Conclusion: The prevalence of PO was 59%, being more frequent at the femoral level. Larger studies must be carried out to determine the clinical significance of radiologic PO.

Keywords: periprosthetic osteolysis, hip prosthesis, rheumatoid arthritis, juvenile chronic arthritis, ankylosing spondylitis

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