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Prevalence of Frailty and Evaluation of Associated Variables Among COPD Patients

Authors Dias LS, Ferreira ACG, Silva Junior JLR, Conte MB, Rabahi MF

Received 18 February 2020

Accepted for publication 24 May 2020

Published 12 June 2020 Volume 2020:15 Pages 1349—1356

DOI https://doi.org/10.2147/COPD.S250299

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Richard Russell


Lara de Souza Dias,1 Anna Carolina Galvão Ferreira,1 José Laerte Rodrigues da Silva Junior,2 Marcus Barreto Conte,3 Marcelo Fouad Rabahi1

1Faculdade de Medicina, Universidade Federal de Goiás, Goiânia, Goiás, Brasil; 2Faculdade de Medicina, Universidade de Rio Verde, Aparecida de Goiânia, Goiás, Brasil; 3Faculdade de Medicina, Faculdade Arthur Sá Earp Neto, Petrópolis, Rio de Janeiro, Brasil

Correspondence: Lara de Souza Dias Viela Gabriela Augusta Nascimento Qd.B Lt.7H Centro, CEP:75640-000, Piracanjuba, Goiás, Brasil
Email laradias_1@hotmail.com

Rationale: Frailty in chronic obstructive pulmonary disease (COPD) patients has been associated with a higher rate of incidents, longer duration of hospitalization, poorer quality of life, and higher mortality.
Objective: To measure the prevalence of frailty among COPD patients and to evaluate associated variables.
Methods: A cross-sectional study. Subjects who visited a State Center for High-Cost Medicines to obtain free monthly COPD medicines were considered eligible. Individuals ≥ 40 years old who had a FEV1/FVC ratio of < 0.7 post-bronchodilation were enrolled. The Fatigue, Resistance, Ambulation, Illnesses, and Loss of weight (FRAIL) scale, Medical Research Council dyspnea scale (MRC), COPD Assessment Test (CAT), a combination of CAT/MRC [(CAT/8)+MRC], and the Global Initiative for Chronic Obstructive Lung Disease (GOLD) severity scale were used to evaluate the enrolled subjects. Variables associated with frailty were analyzed using an ordered logistic regression and a multivariate logistic regression.
Results: The prevalence of frailty and pre-frailty among the 153 COPD subjects enrolled was 50.3% (77/153) and 35.3% (54/153), respectively. Frailty scores were correlated with CAT (correlation coefficient [cc]: 0.52, p < 0.001) and MRC (cc: 0.48, p < 0.001). Ordinal regression models showed that MRC and CAT were associated with fragility (p < 0.0001 for both models). Higher odds of frailty were observed in GOLD groups B (p = 0.04) and D (p = 0.02). Multiple logistic regression revealed that the combination CAT/MRC≥ 5.5 was associated with frailty (OR 6.73; p < 0.0001) and had a specificity of 80.3%, sensitivity of 62.3%, and positive and negative predictive values of 76.2% and67.8%, respectively.
Conclusion: Frailty prevalence was high and was correlated with higher MRC and CAT scores. The CAT/MRC combination [(CAT/8)+MRC] ≥ 5.5 was highly associated with frailty, suggesting that an additional specific evaluation for the presence of frailty is indicated.

Keywords: frailty, pulmonary disease, chronic obstructive

Introduction

As a result of an aging population, frailty is a new challenge in public health.1 Frailty can be defined as the loss of an individual’s ability to adapt to stress due to the decrease in or dysfunction of their physiological reserves. This state of physical vulnerability is associated with disability, and an increase in the number of falls, hospitalizations, and death.24 Frailty can result from physiological processes such as aging, or can be associated with chronic diseases such as chronic obstructive pulmonary disease (COPD).48 In fact, the prevalence of frailty among COPD patients worldwide is estimated to be between 6% and 82%.915

Frailty is a dynamic condition. Frail COPD patients are more likely to be unable to complete rehabilitation programs, and mortality amongst these patients is 80% higher than for non-frail patients.12,13 A study that followed up COPD patients from the National Emphysema Treatment Trial (NETT) for 24 months compared participants with two or fewer frailty parameters to those with three or more frailty parameters. The incidence rate of frailty was 6.4 per 100 person-years. Analysis revealed that frailty was associated with a higher rate and longer-duration hospitalization, and with poor quality of life.10 In Brazil, the prevalence of frailty and the predictive variables associated with frailty among COPD subjects are unknown. The aim of this study was to measure the prevalence of frailty among COPD patients in Goiania city (Brazil) and to evaluate the association between predictive variables and the presence of frailty.

Methods

Design

This was an observational cross-sectional study.

Setting

The study was conducted at the Juarez Barbosa State Center for High-Cost Medicines (CEMAC), a public center responsible for providing free medicines for COPD treatment for Brazilians without socioeconomic distinction, located in Goiania city, Brazil. Data were collected from January 18th, 2018 to December 14th, 2018.

Subject Selection

All patients who reported a COPD diagnosis when visiting CEMAC to obtain free monthly COPD medicines were considered eligible. Individuals of ≥40 years of age who had a forced expiratory volume in the first second/forced vital capacity (FEV1/FVC) ratio of <0.7 post-bronchodilator documented on a pulmonary function test were enrolled. Written informed consent was obtained from all participants. Subjects were excluded if they did not complete interviews, questionnaires, or tests.

Data Collection and Diagnostic Procedures

Data were collected by one physician (ACGF) and one physical therapist (LSD) specifically trained for this purpose using a study-specific data collection instrument. The data collection instrument was pre-tested, validated, and modified during a study conducted from December 1st, 2017 to December 15th, 2017 in eight COPD patients. These subjects were not included in the study. Variables assessed by the data collection instrument included sociodemographic data, tobacco smoking, level of dyspnea, clinical impact of symptoms, medicines prescribed for COPD treatment, and total number of exacerbations in the last 12 months.

Frailty was evaluated through the Fatigue, Resistance, Ambulation, Illnesses, and Loss of weight (FRAIL) scale, a questionnaire with five self-report items for which the possible answers are “yes” or “no”, with an attribution of 1 or 0 points, respectively. The individuals were classified as non-frail (0 points), pre-frail (1 or 2 points), and frail (3 or more points).16,17

Comorbidities were evaluated using the Charlson Comorbidity Index (CCI).18 The patient’s score is calculated as the sum of the weights of all presented comorbidities that are components of the index, and from 50 years on, an additional weight is added to each decade of life.18 Dyspnea was assessed using the Medical Research Council (MRC) dyspnea scale, a scale consisting of five gradations of dyspnea, where each item corresponds to how much the dyspnea limits activities involved in daily life.19 The COPD Assessment Test (CAT) was applied to evaluate the impact of COPD on quality of life.20 This test consists of eight items: cough, phlegm, chest tightness, shortness of breath, activity limitations at home, confidence in leaving home, sleep, and energy. Each item is given a score from 0 to 5. By summing the score of each item, patients can be classified according to the clinical impact of the disease: mild (6 to 10 points), moderate (11 to 20 points), severe (21 to 30 points), and very severe (31 to 40 points).20,21

The diagnosis of COPD was confirmed by the presence of respiratory symptoms associated with a history of exposure to tobacco or biomass, and a documented pulmonary function test with an FEV1/FVC ratio of <0.7 post-bronchodilator.22 The severity of the condition was assessed by considering the patient’s health status according to CAT, and the number of exacerbations and the need for hospitalization in the last 12 months, as previously described in the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines.22

To minimize compliance bias (as the level of fragility would increase among individuals who were not on regular treatment because of low financial condition) we selected a public center providing free medication. Measurement bias was approached by using a pre-tested and validated study-specific data collection instrument applied by the same research team (ACGF and LSD), and to minimize random bias, we use consecutive recruitment.

Statistical Analysis

“Non-frail”, “pre-frail”, and “frail” were considered as outcome variables. The following predictive variables were assessed: symptoms according to CAT score, sociodemographic data, body mass index (BMI), comorbidities (CCI), risk factors (smoking), number of exacerbations, and disease severity.

To verify that predictive variables were associated with outcomes, two approaches were taken. In the first, a linear regression analysis was performed. Spearman correlation (r) was calculated to analyze the strength of associations. Then, a multiple linear regression model was created, including gender as well as variables with a p-value<0.20. In the second approach, COPD patients were classified into three categories: non-frail, pre-frail, and frail. Variables were compared using Pearson’s chi-square test or Fisher’s exact test, when applicable. The Kruskal–Wallis test with a post-hoc comparison (Dunn’s test) was used to compare the medians of quantitative variables. Then, variables with a p value<0.20 and gender were included in ordinal regression models. In these models, the dependent variable was the frailty level, stratified into three categories (non-frail[1], pre-frail [2], and frail [3]). The magnitudes of the associations were presented as regression coefficients (β) and adjusted odds ratios (ORaj) with confidence intervals (CI) of 95%. As GOLD categories were derived from CAT, two ordinal regression models were adjusted including the variables separately. The ordinal regression models were evaluated and validated to confirm the proportional odds assumption using a likelihood-ratio test and a Brant test. As MRC and CAT were predictors of frailty, we created a new variable that could express both parameters simultaneously. As the CAT can assume values up to 8 times the MRC, so that the CAT does not conceal MRC value, a new variable (CAT/MRC) was created by dividing the CAT by 8, followed by the sum of MRC: (CAT/8) + MRC. Then, we coded frailty in a binary outcome ([0] non-frail and pre-frail;[1] frail) to create a multivariate logistic regression model to assess the association between the presence of frailty and new independent variable CAT/MRC, while controlling for sex, FEV1 and inhaled medications. The cutoff value of the CAT/MRC as a frailty predictor was calculated by use of a receiver operating characteristic (ROC) curve. A p value of <0.05 was considered statistically significant. Data were analyzed using STATA software, version 15.0 (StataCorp, Texas, USA).

Sample Size

The sample size calculation was performed by estimating the proportion of the population with specified absolute precision (n = z21-α/2P(1-P)/d2). At a confidence level of 95%, with an absolute accuracy of ± 4% in the study proportion measure, and considering the prevalence of frailty in COPD patients as 6.6%, a sample of 148 subjects was estimated.11

Ethical Aspects

All participants gave written informed consent in accordance with the principles of Good Clinical Practice and the Declaration of Helsinki and the study was approved by the Institutional Review Board (IRB) of the Federal University of Goias under the following number: 2,403,289. CAAE 79462917.9.0000.5078. Approval was granted on November 28th, 2017.

Results

A total of 203 individuals visited CEMAC to obtain medicines for COPD treatment during the study period.22% (45/203) were not COPD patients, but were individuals authorized to withdraw medicines on behalf of COPD patients. 2.4% (5/203) of subjects refused to participate in the study. Table 1 shows the characteristics of the 153 COPD patients enrolled in this study and their frailty state.

Table 1 Characteristics of 153 COPD Patients Classified by Their Frailty State

The prevalence of frailty in the sample was 50.3% (77/153), while 35.3% (54/153) of patients were pre-frail and 14.4% (22/153) were non-frail. The education level and FEV1 (%) were significantly lower and the MRC and CAT scores were significantly higher in the frail group.

Figures 1 and 2 show the correlations between frailty score and CAT score (correlation coefficient: 0.52, p <0.001) and between frailty score and MRC score (correlation coefficient: 0.48, p <0.001)

Figure 1 Correlation between FRAIL scale and COPD Assessment Test (CAT) scores in patients with COPD.

Figure 2 Correlation between FRAIL scale and Medical Research Council (MRC) Dyspnea Scale scores in patients with COPD.

The regression model presented in Table 2 shows that the odds of frailty increased with increasing MRC score (Model 1: ORaj = 1.94; p <0.0001; Model 2: ORaj = 1.55; p=0.01). Considering model 1, for every one unit increase in the MRC score the odds of being pre-frail or frail, versus non-frail is multiplied 1.94 times (increases 94%), holding constant all other variables. For model 2, the increase is 1.55 times or 55%. Because of the proportional odds assumption of ordinal regression, there is a reduction of 1.94 times or 1.55 times, in the odds of being frail versus the combined categories of pre-frail and non-frail when MRC reduces one unit.GOLD B (ORaj = 2.46; p = 0.04) and D (ORaj = 3.41; p = 0.02) COPD patients had an increased chance of frailty compared to GOLD A patients. For COPD patients GOLD B the odds of being frail is 2.46 times (or 146% more) that of who were not GOLD B, holding constant all other variables. The same interpretation applies to GOLD D (3, 41 times or 241%). Also, it was found that the chance of frailty was directly related to an increase in CAT score (ORaj = 1.15; p <0.0001), that is, for every one unit increase in the CAT score the odds of being pre-frail or frail, versus non-frail is multiplied 1.15 times (increases 15%), holding constant all other variables (Table 2). Adjusting for sex, FEV1 and inhaled medications, multiple logistic regression analysis revealed that CAT/MRC was an independent predictor of frailty (ORaj = 1.86; p <0.0001) (Table 2). The area under the ROC curve of CAT/MRC combination was 0.79 (95% CI 0.72–0.86) (Figure 3). Comparing the sensibility, specificity, positive and negative predictive value, and area under the ROC curve of each CAT/MRC cutoff, the best combination without a significant loss in sensibility was CAT/MRC≥5.5 (OR 6.73; 95% CI 3.26–13.9; p <0.0001). CAT/MRC≥5.5had a specificity of 80.3% (95% CI 69.5%-88.5%); sensitivity of 62.3% (95% CI 50.6%-73.1%); positive and negative predictive values of 76.2% (95% CI 66.3%-83.9%), and67.8% (95% CI 60.7%-74.1%), respectively.

Table 2 Regression Model Evaluating Predictive Variables Associated with Frailty Among the 153 COPD Patients Enrolled in the Study

Figure 3 ROC curve of CAT/MRC combination [(CAT/8)+MRC] to identify frailty in COPD patients.

Discussion

The prevalence of frailty among the 153 COPD patients evaluated was 50.3% (77/153) and the prevalence of pre-frailty was 35.3% (54/153). The level of dyspnea according to the MRC, the health status according to the CAT score, and COPD groups B or D according to the GOLD severity score were associated with frailty state. According to the literature, frailty prevalence in COPD patients varies from 6% to 82%.6,915 This large variability could be explained by differences in demographics, disease severity, and comorbidities amongst study samples. Our findings are similar to the study of Park et al (2013) that found a prevalence of frailty of 57.8% in 211 COPD patients and a direct association between dyspnea and frailty.23 On the other hand, a frailty prevalence of 82% was found in another study evaluating a sample of COPD patients with a mean age of 65 years,93.2% of whom were classified into groups B and D on the GOLD severity score, and 43% of whom had two or more comorbidities.13 Our sample also included moderate to severe COPD patients with a similar mean age, and found a much lower frailty prevalence (50.3%). It is possible that the provision of free medicines to subjects in our sample could increase treatment adherence and have some impact on disease control and frailty prevalence. Also, the present study used the FRAIL scale to define frailty, whereas different studies have used other scales such as the Frail Non-Disabled (FIND) questionnaire, the Kihon Checklist, and the Modified Frailty Index. This also could impact on the measurement of frailty prevalence.13,15,24

In our study, we found a significant association between frailty and CAT. Similar results were found by Maddocks and Ierodiakonou, who besides demonstrating that CAT was a predictor of frailty, additionally found that higher CAT was associated with failure to complete a rehabilitation program.12,13 Lahousse et al (2016) also found a higher prevalence of frailty among COPD patients with GOLD severity scores B and D.14 This increased risk of frailty among GOLD severity groups B and D is probably associated with the MRC and CAT scores, since both of these parameters are used to stratify COPD patients as GOLD B or D groups, patients in group D are 8 times more likely to present frailty than the others and group B has a high prevalence of the syndrome.25 We did not find a statistical difference between the frailty categories regarding inhaled corticosteroids or bronchodilators, but a predominance of double or triple therapy (LABA+LAMA or LABA+LAMA+IC) was observed in the pre-frail or frail groups. Fragility is associated with dyspnea, and as it increases, there is a need to introduce more than one bronchodilator, as described in the GOLD guidelines.22 However, Pei-Ju Chen et al found that the number of medications used, was a predictor of frailty in COPD patients with and without dyspnea, irrespective of being bronchodilators.26

In our sample, there was no association between BMI and FRAIL score. This finding is similar to that of a study of 121 COPD patients conducted by Limpawattana et al (2017).11 In fact, although a loss of muscle mass can be found in COPD patients, BMI has not been associated with frailty, although fragility and malnutrition often coexist.27,28

In our sample, FEV1 was lower for frail patients. However, there was no difference in the FEV1/FVC ratio between frail and non-frail individuals (Table 1). Kusunose et al (2017), in a study of patients with mild to severe airflow limitation, also found a lower FEV1among frail subjects and no differences in FEV1/FVC or Total Lung Capacity (TLC) between the groups studied.15 In fact, FEV1 describes airflow limitation better than the FEV1/FVC ratio and is, therefore, the parameter used to classify COPD severity internationally.22

The present study has an important limitation. Patients were invited to take part in the study when visiting the CEMAC public center in order to obtain free COPD medicines. Since the medicines can be picked up by subjects other than the patients themselves, some COPD patients with limited mobility may not have attended CEMAC in person and thus could not be invited to participate in the study. Therefore, a selection bias is possible and the results should be not extrapolated to COPD patients who have restricted mobility.

Conclusion

Frailty has a great clinical impact, but it is not routinely investigated in COPD patients. In this sample of COPD patients, the frailty prevalence was high and was associated with higher MRC and CAT scores, parameters used routinely in the management of COPD and included in the ABCD assessment tool of the Global Initiative for Chronic Obstructive Lung Disease. As the combination of CAT/8+MRC≥5.5 was highly associated with frailty, an additional specific evaluation for the presence of frailty is indicated. If this combination is used as predictive tool for early identification of frailty, new therapeutic interventions can be made, helping doctors to better manage their patients on the risks and prognosis associated with frailty.

Acknowledgments

The authors thank the COPD patients who participated in this study and CEMAC.

Author Contributions

All authors contributed to data analysis, drafting or revising the article, gave final approval of the version to be published, and agree to be accountable for all aspects of the work.

Disclosure

Ms Anna Carolina Galvão Ferreira reports a PhD scholarship from Fundação de Amparo Pesquisa do Estado de Goiás - FAPEG, personal fees from Boehringer Ingelheim, personal fees from Novartis, outside the submitted work. Prof. Dr. Marcelo Fouad Rabahi reports grants from CNPq, personal fees from Boehringer Ingelheim, personal fees from AstraZeneca, outside the submitted work. The authors report no other conflicts of interest in this work.

References

1. Dent E, Martin FC, Bergman H, Woo J, Romero-ortuno R, Walston JD. Management of frailty: opportunities, challenges, and future directions. Lancet. 2019;394(10206):1376–1386. doi:10.1016/S0140-6736(19)31785-4

2. Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56A(3):M146–56. doi:10.1093/gerona/56.3.M146

3. Van Kan GA, Rolland YM, Morley JE, Vellas B. Frailty: toward a clinical definition. JAMDA. 2008;9(2):71–72. doi:10.1016/j.jamda.2007.11.005

4. Hoogendijk EO, Afilalo J, Ensrud KE, Kowal P, Onder G, Fried LP. Frailty: implications for clinical practice and public health. Lancet. 2019;394(10206):1365–1375. doi:10.1016/S0140-6736(19)31786-6

5. Vermeiren S, Vella-Azzopardi R, Beckwée D, et al. Frailty and the prediction of negative health outcomes: a meta-analysis. JAMDA. 2016;17(12):1163.e1e1163.e17.

6. Galizia G, Cacciatore F, Testa G, et al. Role of clinical frailty on long-term mortality of elderly subjects with and without chronic obstructive pulmonary disease. Aging Clin Exp Res. 2011;23(2):118–125.

7. Madan SA, Fida N, Barman P, et al. Frailty assessment in advanced heart failure. J Card Fail. 2016;22(10):840–844. doi:10.1016/j.cardfail.2016.02.003

8. Denfeld QE, Winters-stone K, Mudd JO, Gelow JM, Kurdi S, Lee CS. The prevalence of frailty in heart failure: a systematic review and meta-analysis. Int J Cardiol. 2017;01(236):283–289. doi:10.1016/j.ijcard.2017.01.153

9. Marengoni A, Vetrano DL, Manes-Gravina E, Bernabei R, Onder G, Palmer K. The relationship between COPD and frailty. Chest. 2018;154(1):21–40. doi:10.1016/j.chest.2018.02.014

10. Kennedy CC, Novotny PJ, LeBrasseur NK, Wise RA, Sciurba FC, Benzo RP. Frailty and clinical outcomes in chronic obstructive pulmonary disease. Annalsats. 2018;16(2):1–34.

11. Limpawattana P, Putraveephong S, Inthasuwan P, Boonsawat W, Theerakulpisut D, Chindaprasirt J. Frailty syndrome in ambulatory patients with COPD. Int J COPD. 2017;12(134233):1193–1198. doi:10.2147/COPD.S134233

12. Maddocks M, Kon SSC, Canavan JL, et al. Physical frailty and pulmonary rehabilitation in COPD: a prospective cohort study. Thorax. 2016;71(11):988–995. doi:10.1136/thoraxjnl-2016-208460

13. Ierodiakonou D, Kampouraki M, Poulonirakis I, et al. Determinants of frailty in primary care patients with COPD: the Greek UNLOCK study. BMC Pulm Med. 2019;19(1):1–9.

14. Lahousse L, Ziere G, Verlinden VJA, et al. Risk of frailty in elderly with COPD: a population-based study. J Gerontol A Biol Sci Med Sci. 2016;71(5):689–695. doi:10.1093/gerona/glv154

15. Kusunose M, Oga T, Nakamura S, Hasegawa Y, Nishimura K. Frailty and patient-reported outcomes in subjects with chronic obstructive pulmonary disease: are they independent entities? BMJ Open Respir Res. 2017;4(1):1–7.

16. Morley JE, Malmstrom TK, Miller DK. A simple frailty questionnaire (FRAIL) predicts outcomes in middle aged African Americans. J Nutr Health Aging. 2012;16(7):601–608. doi:10.1007/s12603-012-0084-2

17. Aprahamian I, Lin SM, Suemoto CK, et al. Feasibility and factor structure of the FRAIL scale in older adults. JAMDA. 2017;18(4):367.e11e367.e18.

18. Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40(5):373–383.

19. Kovelis D, Segretti NO, Probst VS, Lareau SC, Brunetto AF, Pitta F. Validation of the modified pulmonary functional status and dyspnea questionnaire and the medical research council scale for use in Brazilian patients with chronic obstructive pulmonary disease. J Bras Pneumol. 2008;34(12):1008–1018. doi:10.1590/S1806-37132008001200005

20. Jones PW, Harding G, Berry P, Wiklund I, Chen WH, Kline Leidy N. Development and first validation of the COPD assessment test. Eur Respir J. 2009;34(3):648–654. doi:10.1183/09031936.00102509

21. Silva GPF, Morano MTAP, Viana CMS, Magalhães CBA, Pereira EDB. Validation of the COPD Assessment Test in Portuguese for use in Brazil. J Bras Pneumol. 2013;9(4):402–408.

22. Global Initiative for Chronic Obstructive Lung Disease. Report. Global Initiative for Chronic Obstructive Lung Disease: Pocket Guide to COPD Diagnosis, Management and Prevention: A Guide for Health Care Professionals 2019; 2019.

23. Park SK, Richardson CR, Holleman RG, Larson JL. Physical activity in people with COPD, using the national health and nutrition evaluation survey dataset (2003-2006). Hear Lung J Acute Crit Care. 2013;42(4):235–240. doi:10.1016/j.hrtlng.2013.04.005

24. Valenza MC, Torres-Sánchez I, Cabrera-Martos I, Rodríguez-Torres J, González-Jiménez E, Muñoz-Casaubon T. Physical activity as a predictor of absence of frailty in subjects with stable COPD and COPD exacerbation. Respir Care. 2016;61(2):212–219. doi:10.4187/respcare.04118

25. Mihaltan F, Adir Y, Antczak A, et al. Importance of the relationship between symptoms and self-reported physical activity level in stable COPD based on the results from the SPACE study. Respir Res. 2019;20(1):1–11. doi:10.1186/s12931-019-1053-7

26. Chen PJ, Yang KY, Perng WC, Lin KC, Wang KY. Effectofdyspneaonfrailtystagesandrelatedfactors in Taiwanesemenwith COPD. Int J ChronObstructPulmonDis. 2018;13:2463–2469. doi:10.2147/COPD.S172694

27. Marchioro J, Gazzotti MR, Moreira GL, et al.; PLATINO Team. Análise evolutiva antropométrica em indivíduos com DPOC na cidade de São Paulo - estudo de base populacional. J Bras Pneumol. 2019;45(6):e20170157.

28. Beek L, van der Vaart H, Wempe JB, et al. Coexistence of malnutrition, frailty, physical frailty and disability in patients with COPD starting a pulmonary rehabilitation program. Clin Nutr. 2019;S0261-5614(19):33143–33147. doi:10.1016/j.clnu.2019.11.016

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