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Prediction of population with Alzheimer's disease in the European Union using a system dynamics model

Authors Tomaskova H, Kuhnova J, Cimler R, Dolezal O, Kuca K

Received 7 March 2016

Accepted for publication 12 April 2016

Published 30 June 2016 Volume 2016:12 Pages 1589—1598

DOI https://doi.org/10.2147/NDT.S107969

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Chin-Pang Lee

Peer reviewer comments 2

Editor who approved publication: Dr Roger Pinder


Hana Tomaskova,1 Jitka Kuhnova,2 Richard Cimler,1,3 Ondrej Dolezal,1 Kamil Kuca3

1Faculty of Informatics and Management, 2Faculty of Science, 3Center for Basic and Applied Research (CZAV), University of Hradec Králové, Hradec Králové, Czech Republic

Introduction: Alzheimer’s disease (AD) is a slowly progressing neurodegenerative brain disease with irreversible brain effects; it is the most common cause of dementia. With increasing age, the probability of suffering from AD increases. In this research, population growth of the European Union (EU) until the year 2080 and the number of patients with AD are modeled.
Aim: The aim of this research is to predict the spread of AD in the EU population until year 2080 using a computer simulation.
Methods: For the simulation of the EU population and the occurrence of AD in this population, a system dynamics modeling approach has been used. System dynamics is a useful and effective method for the investigation of complex social systems. Over the past decades, its applicability has been demonstrated in a wide variety of applications. In this research, this method has been used to investigate the growth of the EU population and predict the number of patients with AD. The model has been calibrated on the population prediction data created by Eurostat.
Results: Based on data from Eurostat, the EU population until year 2080 has been modeled. In 2013, the population of the EU was 508 million and the number of patients with AD was 7.5 million. Based on the prediction, in 2040, the population of the EU will be 524 million and the number of patients with AD will be 13.1 million. By the year 2080, the EU population will be 520 million and the number of patients with AD will be 13.7 million.
Conclusion: System dynamics modeling approach has been used for the prediction of the number of patients with AD in the EU population till the year 2080. These results can be used to determine the economic burden of the treatment of these patients. With different input data, the simulation can be used also for the different regions as well as for different noncontagious disease predictions.

Keywords: Alzheimer’s disease, population modeling, system dynamics, prediction model

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