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Potential use of mesenchymal stem cells in human meniscal repair: current insights

Authors Pak J, Lee JH, Park KS, Jeon JH, Lee SH

Received 17 January 2017

Accepted for publication 2 March 2017

Published 23 March 2017 Volume 2017:8 Pages 33—38

DOI https://doi.org/10.2147/OAJSM.S113018

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Andreas Imhoff

Jaewoo Pak,1–3* Jung Hun Lee,1,4* Kwang Seung Park,4 Jeong Ho Jeon,4 Sang Hee Lee4

1Stems Medical Clinic, Gangnamgu, Seoul, Republic of Korea; 2TEDA‑Puhua International Hospital, Tianjin, People’s Republic of China; 3Life Science Institute, Komplek Permata Senayan, Jalan Tentara Pelajar, Jakarta Selatan, Indonesia; 4National Leading Research Laboratory, Department of Biological Sciences, Myongji University, Yongin, Gyeonggido, Republic of Korea

*These authors contributed equally to this work

Abstract: The menisci of the human knee play an important role in maintaining normal functions to provide stability and nutrition to the articular cartilage, and to absorb shock. Once injured, these important structures have very limited natural healing potential. Unfortunately, the traditional arthroscopic meniscectomy performed on these damaged menisci may predispose the joint toward early development of osteoarthritis. Although a very limited number of studies are available, mesenchymal stem cells (MSCs) have been investigated as an alternative therapeutic modality to repair human knee meniscal tears. This review summarizes the results of published applications of MSCs in human patients, which showed that the patients who received MSCs (autologous adipose tissue-derived stem cells or culture-expanded bone marrow-derived stem cells) presented symptomatic improvements, along with magnetic resonance imaging evidences of the meniscal repair.

Keywords: adipose tissue-derived stem cells, bone marrow-derived stem cells, human knee, meniscal tear, articular cartilage, therapeutic modality

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