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Polycystic ovary syndrome and mental disorders: a systematic review and exploratory meta-analysis

Authors Blay SL, Aguiar JV, Passos IC

Received 2 July 2016

Accepted for publication 19 September 2016

Published 8 November 2016 Volume 2016:12 Pages 2895—2903

DOI https://doi.org/10.2147/NDT.S91700

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Prof. Dr. Roumen Kirov

Peer reviewer comments 2

Editor who approved publication: Dr Roger Pinder


Sergio Luís Blay,1 João Vicente Augusto Aguiar,2 Ives Cavalcante Passos3

1Department of Psychiatry, Federal University of São Paulo (Escola Paulista de Medicina – UNIFESP), São Paulo, SP, Brazil; 2Department of Psychiatry, Fortaleza University, Fortaleza, Ceará, Brazil; 3Laboratory of Molecular Psychiatry and Department of Psychiatry, Federal University of Rio Grande do Sul, Rio Grande do Sul, Brazil

Background: The association between depression, anxiety, and polycystic ovary syndrome (PCOS) is still unclear. Therefore, a systematic review and meta-analysis was conducted to assess the rates of comorbid psychiatric disorders among women with PCOS compared to women without it.
Methods: PubMed/MEDLINE, Embase, PsycINFO, and Web of Science databases were searched from inception to November 27, 2015. Studies were eligible for inclusion if they were original reports in which the rates of mood (bipolar disorder, dysthymia, or major depressive disorder), obsessive–compulsive spectrum disorders, trauma- and stressor-related disorders, anxiety disorders or psychotic disorders, somatic symptom and related disorders, or eating disorders had been investigated among women with an established diagnosis of PCOS and compared with women without PCOS. Psychiatric diagnosis should have been established by means of a structured diagnostic interview or through a validated screening tool. Data were extracted and pooled using random effects models.
Results: Six studies were included in the meta-analysis; of these, five reported the rates of anxiety and six provided data on the rates of depression. The rate of subjects with anxiety symptoms was higher in patients with PCOS compared to women without PCOS (odds ratio (OR) =2.76; 95% confidence interval (CI) 1.26 to 6.02; Log OR =1.013; P=0.011). The rate of subjects with depressive symptoms was higher in patients with PCOS compared to women without PCOS (OR =3.51; 95% CI 1.97 to 6.24; Log OR =1.255; P<0.001).
Conclusion: Anxiety and depression symptoms are more prevalent in patients with PCOS.

Keywords:
polycystic ovary syndrome, depression, anxiety, epidemiological survey, meta-analysis, systematic review

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