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Plasma levels of IL-6 in patients with untreated major depressive disorder: comparison with catecholamine metabolites

Authors Yoshimura R, Kishi T, Iwata N

Received 20 November 2018

Accepted for publication 29 January 2019

Published 13 September 2019 Volume 2019:15 Pages 2655—2661

DOI https://doi.org/10.2147/NDT.S195379

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 3

Editor who approved publication: Dr Roger Pinder


Reiji Yoshimura,1,* Taro Kishi,2,* Nakao Iwata2

1Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Fukuoka 8078555, Japan; 2Department of Psychiatry, Fujita Medical University, Toyoake Aichi 4701192, Japan

*These authors contributed equally to this work

Correspondence: Reiji Yoshimura
Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu Fukuoka 8078555, Japan
Tell +81936917253
Email yoshi621@med.uoeh-u.ac.jp

Objective: IL-6 and catecholamines play roles in the pathophysiology of major depressive disorder (MDD).
Aim: The present study investigated associations between plasma IL-6 and plasma catecholamine metabolites in patients with MDD.
Participants and methods: A total of 148 patients (male/female 65/83, age 49.5±12.1 years) who met the criteria for MDD based on the Diagnostic and Statistical Manual of Mental Disorders IV and 40 participants as healthy controls (HC; male/female 23/17, age 44.0±10.5 years) were enrolled in the present study. Plasma levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) and homovanillic acid (HVA) were analyzed using high-performance liquid chromatography, and plasma IL-6 levels were measured using ELISA.
Results: No correlations were observed among plasma IL-6 levels, MHPG levels, and HVA levels in patients with MDD. Plasma IL-6 levels in patients with MDD were significantly higher than in the HC. A positive correlation was found between plasma IL-6 levels and Hamilton Rating Scale for Depression-17 scores.
Conclusion: No correlations existed between plasma IL-6 levels and plasma catecholamine metabolite levels in patients with MDD, and the severity of depressive state was related to plasma IL-6 levels in MDD.

Keywords: IL-6, 3-methoxy-4-hydroxyphenylglycol, homovanillic acid, major depressive disorder, Hamilton Rating Scale for Depression

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