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Plasma fibrinogen and serum albumin levels (FA score) act as a promising prognostic indicator in non-small cell lung cancer

Authors Chen P, Wang C, Cheng B, Nesa EU, Liu Y, Jia Y, Qu Y, Jiang Z, Han J, Cheng Y

Received 5 April 2017

Accepted for publication 22 May 2017

Published 21 June 2017 Volume 2017:10 Pages 3107—3118

DOI https://doi.org/10.2147/OTT.S138854

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Ru Chen

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Geoffrey Pietersz

Pengxiang Chen,1 Cong Wang,1 Bo Cheng,2 Effat Un Nesa,1 Yuan Liu,1 Yibin Jia,1 Yan Qu,1 Ziying Jiang,1 Jie Han,3 Yufeng Cheng1

1Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, 2Medical College of Qingdao University, Qingdao, 3Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong University, Jinan, People’s Republic of China


Background: Evidence implies that preoperative plasma fibrinogen and serum albumin are associated with cancer prognosis. We aimed to explore the prognostic values of the score based on plasma fibrinogen and serum albumin levels (FA score) in non-small cell lung cancer (NSCLC), and to compare that with prognostic nutritional index (PNI).
Patients and methods: In all, 182 patients pathologically diagnosed with NSCLC were included in this study. Kaplan–Meier survival analysis and multivariate analysis were used in the prognostic analyses.
Results: High FA score was related to smoking (P=0.005), poor differential grade (P=0.002), and advanced T stage (P<0.001) and tumor, node, and metastases stage (P=0.011). Low PNI showed association with advanced T stage (P=0.030). Kaplan–Meier survival analysis indicated that high FA score and low PNI were associated with poor progression-free survival (PFS; for the FA score, P<0.001; for PNI, P=0.001) and overall survival (OS; for the FA score, P<0.001; for PNI, P=0.013), respectively. Multivariate analysis revealed that FA score was an independent predictor for PFS (P=0.003) and OS (P=0.001) in NSCLC patients.
Conclusion: The FA score could act as a more promising prognostic predictor than PNI in NSCLC patients who underwent pneumonectomy.

Keywords: non-small cell lung cancer, surgical treatment, serum albumin, plasma fibrinogen, prognostic nutritional index, prognosis

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