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PDLA a potential new potent topical analgesic: a case report

Authors Goldberg J

Received 9 August 2014

Accepted for publication 26 August 2014

Published 24 October 2014 Volume 2014:7 Pages 59—61

DOI https://doi.org/10.2147/LRA.S72481

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Stefan Wirz


Joel S Goldberg1,2

1Durham Veterans Affairs Medical Center, 2Duke University School of Medicine, Durham, NC, USA

Abstract: Polymer D-lactic acid (PDLA) is a hydrogel that has been shown to sequester L-lactate (lactate). This reaction is rapid, spontaneous, and non-enzymatic. Lactate has been shown to have many functions within the nervous system including its use as a secondary fuel to sustain neural activity and as a neuromodulator. In the central nervous system, lactate is produced in glial cells and shuttled to neurons to be used mostly as a fuel. Lactate dehydrogenase (LDH)1 is the predominant LDH isoform within neurons and unlike LDH5, it preferentially converts lactate to pyruvate which can be used to produce adenosine triphosphate (ATP). Considering that lactate is intimately involved in the sustenance of neural activity, PDLA was applied to an open wound and its effects were examined. The results showed that the application of PDLA induced topical analgesia. This may be the first report to demonstrate that sequestering lactate, a source of energy required to sustain the firing of action potentials in neurons, may produce analgesia.

Keywords: polymer D-lactic acid, topical analgesia, hydrogel

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