Back to Journals » International Journal of Chronic Obstructive Pulmonary Disease » Volume 10 » Issue 1

Pathological and radiological correlation in an autopsy case of combined pulmonary fibrosis and emphysema

Authors Karata H, Tanaka T, Egashira R, Tabata K, Otani K, Hayashi R, Hori T, Fukuoka J

Received 25 February 2015

Accepted for publication 27 April 2015

Published 8 July 2015 Volume 2015:10(1) Pages 1299—1303

DOI https://doi.org/10.2147/COPD.S83521

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Richard Russell

Hiroki Karata,1 Tomonori Tanaka,1 Ryoko Egashira,2 Kazuhiro Tabata,1 Kyoko Otani,3 Ryuji Hayashi,4 Takashi Hori,5 Junya Fukuoka1

1Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan; 2Department of Radiology, Faculty of Medicine, Saga University, Saga, Japan; 3Department of Diagnostic Pathology, Kobe University Graduate School of Medicine, Kobe, Japan; 4Department of Internal Medicine, University of Toyama, Faculty of Medicine, Toyama, Japan; 5Laboratory of Pathology, Toyama University Hospital, Toyama, Japan

Abstract: We report an educational autopsy case of combined pulmonary fibrosis and emphysema. Radiological patterns of the upper lung were considered as mostly emphysema, but pathological observation revealed significant interstitial fibrosis of usual interstitial pneumonia as a major pathology. The patient eventually developed acute exacerbation of background interstitial pneumonia. Careful radiological and pathological correlation of the current case indicates that regions with distal acinar emphysema on computed tomography image may possess histologically marked dense fibrosis of lethal interstitial pneumonia.

Keywords: interstitial pneumonia, CPFE, AEF, smoking, CT

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Readers of this article also read:

Is a previous diagnosis of asthma a reliable criterion for asthma–COPD overlap syndrome in a patient with COPD?

Barrecheguren M, Román-Rodríguez M, Miravitlles M

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1745-1752

Published Date: 1 September 2015

Safety of inhaled glycopyrronium in patients with COPD: a comprehensive analysis of clinical studies and post-marketing data

D’Urzo AD, Kerwin EM, Chapman KR, Decramer M, DiGiovanni R, D’Andrea P, Hu H, Goyal P, Altman P

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1599-1612

Published Date: 11 August 2015

Prevalence of chronic obstructive pulmonary disease among patients with systemic arterial hypertension without respiratory symptoms

Rabahi MF, Pereira SA, Silva Júnior JL, Rezende AP, Castro da Costa A, Corrêa KS, Conde MB

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1525-1529

Published Date: 31 July 2015

Is asymptomatic peripheral arterial disease associated with walking endurance in patients with COPD?

Sun KS, Lin MS, Chen YJ, Chen YY, Chen SC, Chen W

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1487-1492

Published Date: 29 July 2015

Positioning new pharmacotherapies for COPD

Barjaktarevic IZ, Arredondo AF, Cooper CB

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1427-1442

Published Date: 24 July 2015

Underdiagnosis and prognosis of chronic obstructive pulmonary disease after percutaneous coronary intervention: a prospective study

Almagro P, Lapuente A, Pareja J, Yun S, Garcia ME, Padilla F, Heredia JL, De la Sierra A, Soriano JB

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1353-1361

Published Date: 16 July 2015

Identification of genetic variants in the TNF promoter associated with COPD secondary to tobacco smoking and its severity

Reséndiz-Hernández JM, Sansores RH, Hernández-Zenteno RJ, Vargas-Alarcón G, Colín-Barenque L, Velázquez-Uncal M, Camarena A, Ramírez-Venegas A, Falfán-Valencia R

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1241-1251

Published Date: 29 June 2015

Inflammatory status in older women with and without metabolic syndrome: is there a correlation with risk factors?

Oliveira Silva A, Tibana RA, Karnikowski MGO, Funghetto SS, Prestes J

Clinical Interventions in Aging 2013, 8:361-367

Published Date: 27 March 2013