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Overview of diagnostic/targeted treatment combinations in personalized medicine for breast cancer patients

Authors Tessari A, Palmieri D, Di Cosimo S

Received 20 August 2013

Accepted for publication 15 October 2013

Published 16 December 2013 Volume 2014:7 Pages 1—19

DOI https://doi.org/10.2147/PGPM.S53304

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3


Anna Tessari,1 Dario Palmieri,2 Serena Di Cosimo1

1Division of Medical Oncology 1, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy; 2Molecular Biology and Cancer Genetics, Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, OH, USA

Abstract: Breast cancer includes a body of molecularly distinct subgroups, characterized by different presentation, prognosis, and sensitivity to treatments. Significant advances in our understanding of the complex architecture of this pathology have been achieved in the last few decades, thanks to new biotechnologies that have recently come into the research field and the clinical practice, giving oncologists new instruments that are based on biomarkers and allowing them to set up a personalized approach for each individual patient. Here we review the main treatments available or in preclinical development, the biomolecular diagnostic and prognostic approaches that changed our perspective about breast cancer, giving an overview of targeted therapies that represent the current standard of care for these patients. Finally, we report some examples of how new technologies in clinical practice can set in motion the development of new drugs.

Keywords: breast cancer, biomarkers, gene expression profile, next generation sequencing, targeted therapy

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