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Outcomes of various types of therapy in patients with treatment-resistant acrodermatitis continua of Hallopeau

Authors Smirnova LM, Vertieva EY, Olisova OY, Anpilogova EM

Received 21 December 2018

Accepted for publication 3 April 2019

Published 20 May 2019 Volume 2019:13 Pages 83—87

DOI https://doi.org/10.2147/BTT.S199100

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 3

Editor who approved publication: Dr Doris Benbrook


LM Smirnova, E Yu Vertieva, O Yu Olisova, EM Anpilogova

Department of Dermatology and Venereology, I.M. Sechenov First Moscow State Medical University, Moscow 119991, Russian Federation

Background: Chronic acrodermatitis continua of Hallopeau (ACH) is a rare form of pustular psoriasis predominantly affecting the distal phalanges of the fingers and toes. The disease manifests by pustular rash with marked infiltration, fissures, and often results into severe dystrophy of nail plates. ACH is refractory to most of psoriasis standard of care (SOC) therapies.
Objective: The objective of this study is to assess the prospects of secukinumab therapy of ACH based on current clinical observation.
Methods: We observed a female patient with ACH. Number of SOC treatments were applied in that case including local PUVA therapy, systemic retinoids, methotrexate, and biologic agents.
Result: Secukinumab, a IL-17 inhibitor, demonstrated pronounced clinical effect in the case of ACH refractory to other SOC therapies.
Conclusion: IL-17 inhibition provided by secukinumab was linked to clinically meaningful improvement in the heavily pretreated ACH. Further exploration and clinical studies may be important to provide more data on secukinumab effects in ACH.

Keywords: acrodermatitis continua of Hallopeau, secukinumab, apremilast, anti IL-17A therapy, phosphodiesterase-4

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