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Outcome predictors for treatment success with 5% lidocaine medicated plaster in low back pain with neuropathic components and neuropathic pain after surgical and nonsurgical trauma

Authors Nicolaou, Nicholson, Hans G, Brasseur L

Published 11 January 2011 Volume 2011:4 Pages 25—38


Review by Single-blind

Peer reviewer comments 2

Andrew Nicolaou1, Bruce Nicholson2, Guy Hans3, Louis Brasseur4
1St Georges Hospital, London, UK; 2Allentown, Pennsylvania, USA; 3Antwerp University Hospital, Edegem, Belgium; 4Institut Curie, Saint Cloud, France

Abstract: Five percent lidocaine medicated plaster has been proven efficacious for the symptomatic relief of neuropathic pain in diverse pain conditions which might be attributed to a common localized symptomatology in these indications, possibly with common predictors of treatment success. To discuss potential symptoms and other factors predicting response to treatment with lidocaine plaster for the indications of low back pain with neuropathic components and neuropathic pain after surgical and nonsurgical trauma, 44 pain specialists from 17 countries attended a two-day conference meeting in December 2009. Discussions were based on the retrospective analysis of case reports (sent in by participants in the four weeks prior to the meeting) and the practical experience of the participants. The results indicate some predictors for success with 5% lidocaine medicated plaster for the two indications. Localized pain, hyperalgesia and/or allodynia, and other positive sensory symptoms, such as dysesthesia, were considered positive predictors, whereas widespread pain and negative sensory symptoms were regarded as negative predictors. Paresthesia, diagnosis, and site of pain were considered to be of no predictive value. Common symptomatology with other neurologic pathologies suggests that treatment of localized neuropathic pain symptoms with the plaster can be considered across different neuropathic pain indications.

Keywords: lidocaine plaster, low back pain, surgical and nonsurgical trauma pain, neuropathic pain, case report

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