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Onychomadesis associated with chemotherapy: case report and mini literature review

Authors Li A, Li Y, Ge L, Li P, Li W

Received 14 April 2017

Accepted for publication 6 July 2017

Published 14 August 2017 Volume 2017:11 Pages 2373—2376


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Sukesh Voruganti

Ang Li,1,2,* Yanqiong Li,1,3,* Lingzhi Ge,4 Ping Li,1,3 Wenfei Li1

1Department of Dermatology, Qianfoshan Hospital, Shandong University, Jinan, People’s Republic of China; 2Department of Clinical Medicine, Queen Mary School, Medical School, Nanchang University, Nanchang, People’s Republic of China; 3Department of Clinical Medicine, Taishan Medical college, Tai’an, People’s Republic of China; 4Department of Dermatology, Affiliated First Hospital of Taishan Medical college, Tai’an, People’s Republic of China

*These authors contributed equally to this work

Abstract: The side effects of chemotherapy drugs have increased in recent years, and some side effects can lead to onychomadesis. A 72-year-old woman who was diagnosed with an invasive ductal carcinoma of the right breast underwent a modified radical mastectomy in April 2015, followed by chemotherapy with capecitabine and nanoparticle albumin-bound paclitaxel (nab-paclitaxel). Subsequently, the patient experienced palmoplantar redness, pain, onycholysis, a transparent serous exudate, and onychomadesis. The chemotherapy was discontinued, and the patient was treated with oral vitamin B6, a polymyxin ointment, and a high-energy red light. The palmoplantar redness and pain were alleviated after 1 month. However, although her fingernails improved, dysesthesia symptoms remained, and all her toenails exhibited defects or deformities at a 24-month follow-up. The symptoms of this disorder should be recognized by dermatologists.

Keywords: capecitabine and nab-paclitaxel, side effects, onychomadesis loss of nail

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