Back to Journals » Oncolytic Virotherapy » Volume 4

Oncolytic virotherapy using herpes simplex virus: how far have we come?

Authors Sokolowski N, Rizos H, Diefenbach R

Received 21 July 2015

Accepted for publication 16 October 2015

Published 25 November 2015 Volume 2015:4 Pages 207—219

DOI https://doi.org/10.2147/OV.S66086

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Malathi Krishnamurthy

Peer reviewer comments 5

Editor who approved publication: Dr Faris Farassati


Nicolas AS Sokolowski,1 Helen Rizos,2 Russell J Diefenbach1

1Centre for Virus Research, Westmead Millennium Institute for Medical Research, The University of Sydney, 2Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, NSW, Australia

Abstract: Oncolytic virotherapy exploits the properties of human viruses to naturally cause cytolysis of cancer cells. The human pathogen herpes simplex virus (HSV) has proven particularly amenable for use in oncolytic virotherapy. The relative safety of HSV coupled with extensive knowledge on how HSV interacts with the host has provided a platform for manipulating HSV to enhance the targeting and killing of human cancer cells. This has culminated in the approval of talimogene laherparepvec for the treatment of melanoma. This review focuses on the development of HSV as an oncolytic virus and where the field is likely to head in the future.

Keywords: herpes simplex virus, cancer, immunity, combination therapy, oncolysis

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]