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Oncological outcome after lung metastasis in patients presenting with localized chondrosarcoma at extremities: Tokai Musculoskeletal Oncology Consortium study

Authors Nakamura T, Matsumine A, Yamada S, Tsukushi S, Kawanami K, Ohno T, Katagiri H, Sugiura H, Yamada K, Yamada Y, Sudo A, Nishida Y

Received 2 March 2016

Accepted for publication 10 May 2016

Published 29 July 2016 Volume 2016:9 Pages 4747—4751


Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Manfred Beleut

Peer reviewer comments 5

Editor who approved publication: Dr William Cho

Tomoki Nakamura,1 Akihiko Matsumine,1 Satoshi Yamada,2 Satoshi Tsukushi,3,4 Katsuhisa Kawanami,5 Takatoshi Ohno,6 Hirohisa Katagiri,7 Hideshi Sugiura,3,8 Kenji Yamada,9 Yoshihisa Yamada,10 Akihiro Sudo,1 Yoshihiro Nishida4

1Department of Orthopaedic Surgery, Mie Graduate School of Medicine, Tsu-City, Mie, 2Department of Orthopedic Surgery, Graduate School of Medical Sciences, Nagoya City University, 3Department of Orthopedic Surgery, Aichi Cancer Center Hospital, 4Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi, 5Department of Orthopaedic Surgery, Aichi Medical University School of Medicine, Nagakute, 6Department of Orthopaedic Surgery, Gifu University Graduate School of Medicine, Gifu, 7Division of Orthopaedic Oncology, Shizuoka Cancer Center Hospital, Nagaizumi, Shizuoka, 8Department of Physical Therapy, Nagoya University Graduate School Medicine, Nagoya, 9Department of Orthopedic Surgery, Aichi Cancer Center, Aichi Hospital, Okazaki, 10Department of Orthopedic Surgery, Nagoya Memorial Hospital, Nagoya, Aichi, Japan

Abstract: The oncological outcome after lung metastasis in patients with chondrosarcoma of the extremities has not been reported. Between June 2000 and June 2013, 179 patients with chondrosarcoma in the extremities were treated at eleven hospitals. Twenty consecutive patients (11.2%) developed lung metastases after initial treatment of primary chondrosarcoma in the extremities. We investigated the oncological outcome of 20 chondrosarcoma patients with lung metastasis. There were 14 males and six females with a mean age of 49 years. The mean duration between primary surgery and appearance of lung metastases was 34 months. The mean follow-up period was 48 months. We excluded patients with lung metastasis at the time of presentation from this study. At the final follow-up, four of 20 patients had no evidence of disease, four were alive with disease, and twelve had died of disease. The 3- and 5-year survival rates after lung metastasis were 51.5% and 45.7%, respectively. Tumor grade, extrapulmonary metastasis, and treatment for lung metastases including metastasectomy and radiofrequency ablation were identified by univariate analysis to be significant prognostic factors for oncological analysis. In conclusion, this study evaluated the oncological outcome in patients with chondrosarcoma of the extremities with lung metastasis. Although a large-scale study might be required to confirm the results of this study, we suggest that metastasectomy and/or radiofrequency ablation should be considered to improve postmetastatic survival.

Keywords: chondrosarcoma, lung metastasis, radiofrequency ablation, metastasectomy, extremity

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