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Omadacycline: a novel aminomethylcycline

Authors Burgos RM, Rodvold KA

Received 26 March 2019

Accepted for publication 9 May 2019

Published 2 July 2019 Volume 2019:12 Pages 1895—1915

DOI https://doi.org/10.2147/IDR.S171352

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 3

Editor who approved publication: Dr Joachim Wink


Rodrigo M Burgos,1 Keith A Rodvold1,2

1Department of Pharmacy Practice, University of Illinois at Chicago College of Pharmacy, Chicago, IL, USA; 2Department of Medicine, University of Illinois at Chicago College of Medicine, Chicago, IL, USA

Abstract: Tetracyclines have come a long way since they became available almost seven decades ago, with numerous enhancements allowing new agents to overcome bacterial mechanisms of resistance. However, these enhancements come with toxicities and pharmacokinetic disadvantages such as the gastrointestinal side-effects and poor oral bioavailability seen with the glycylcylcines. Omadacycline, a new and improved tetracycline, has demonstrated a broad spectrum of in vitro activity, has oral and intravenous formulations, improved safety compared to glycylcyclines, as well as clinical efficacy and safety for two types of infections: acute bacterial skin and skin structure infections and community-acquired bacterial pneumonia. This review will summarize salient points about its pharmacologic properties, available clinical efficacy, and safety data and omadacycline’s place in therapy.

Keywords: tetracyclines, community-acquired pneumonia, skin infections
 

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