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Olmesartan Medoxomil, An Angiotensin II-Receptor Blocker, Ameliorates Renal Injury In db/db Mice

Authors Zhu Y, Li ZL, Ding A, Yang H, Zhu WP, Cui TX, Zhang HT, Zhang H

Received 30 May 2019

Accepted for publication 13 September 2019

Published 22 October 2019 Volume 2019:13 Pages 3657—3667

DOI https://doi.org/10.2147/DDDT.S217826

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Melinda Thomas

Peer reviewer comments 2

Editor who approved publication: Dr Anastasios Lymperopoulos


Ye Zhu,1,* Ze-Liang Li,2,* Ao Ding,1,* Hui Yang,3,* Wei-Ping Zhu,1 Tong-Xia Cui,1 Hui-Tao Zhang,4 Hua Zhang1

1Department of Nephrology, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai 519000, People’s Republic of China; 2Department of Medical Imaging, Cangzhou Hospital of Integrated Traditional Chinese Medicine-Western Medicine, Cangzhou 061001, People’s Republic of China; 3Department of Rheumatology, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai 519000, People’s Republic of China; 4Center for Interventional Medicine, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai 519000, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Ye Zhu
Department of Nephrology, The Fifth Affiliated Hospital of Sun Yat-sen University, Mei Hua Dong Road, No. 52, Zhuhai 519000, People’s Republic of China
Tel +86-756-2528701
Email zhuysysu@163.com

Background: Diabetic nephropathy (DN) is a common complication of diabetes mellitus (DM) and also a major cause of end-stage renal disease (ESRD). Olmesartan medoxomil (OM) is an angiotensin II receptor blocker (ARB) and has been shown to exhibit renoprotective effects on a streptozotocin (STZ)-induced diabetic rat model. Yet, whether OM affects DN progression and renal injury in db/db mice, a type 2 diabetic murine model, has not been established.
Methods: Wild-type (n = 15) and db/db mice (n = 15) were treated with control saline or OM via oral gavage. The physiological and biochemical parameters were evaluated and histological examinations of kidney specimens were performed.
Results: Compared with saline-treated db/db mice, db/db mice administered with OM showed ameliorated diabetic physiological and biochemical parameters. In addition, OM decreased urinary albumin excretion and plasma creatinine level in db/db mice. Moreover, histologically, OM reduced glomerular hypertrophy and injury, and also ameliorated tubular injury, thus suggesting that OM improves renal function and minimizes renal pathological deterioration in db/db mice.
Conclusion: Our study reveals a beneficial role of OM in ameliorating DN in db/db mice, which is associated with its renoprotective function.

Keywords: olmesartan medoxomil, angiotensin II, renal injury, diabetic nephropathy, db/db mice

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