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Olfactory functions are not associated with autism severity in autism spectrum disorders

Authors Dudova I, Hrdlicka M

Received 24 September 2013

Accepted for publication 21 October 2013

Published 27 November 2013 Volume 2013:9 Pages 1847—1851

DOI https://doi.org/10.2147/NDT.S54893

Checked for plagiarism Yes

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Peer reviewer comments 2

Iva Dudova, Michal Hrdlicka

Department of Child Psychiatry, University Hospital Motol, Prague, Czech Republic

Background: Changes in olfactory functions have been found in many neurodegenerative and psychiatric disorders, including autism spectrum disorders (ASDs). The aim of the present study was to evaluate the relationship between olfactory functions (odor-detection thresholds, odor identification, and odor preference) and autism severity and sensory-related behavior in children and adolescents with ASD.
Subjects and methods: Our sample consisted of 35 high-functioning patients with ASD (mean age 10.8±3.6 years, 31 boys). Olfactory testing (threshold and identification) used the Sniffin' Sticks test. Odor pleasantness was assessed on a 5-point scale using the Identification part of the Sniffin’ Sticks test. The severity of autistic psychopathology was measured using the Childhood Autism Rating Scale (CARS).
Results: Using Spearman’s correlation, we found no significant correlations between autism severity (as expressed by total CARS score) and odor-detection thresholds (R=0.144, P=0.409), odor identification (R=0.07, P=0.966), or odor pleasantness (R=-0.046, P=0.794). There was also no significant relationship between CARS item 9 (“Taste, smell, and touch response and use”) and odor-detection thresholds (R=0.170, P=0.330), odor identification (R=0.282, P=0.100), or odor pleasantness (R=0.017, P=0.923).
Conclusion: We did not find any significant relationship between the severity of autistic psychopathology and olfactory functions.

Keywords: autism spectrum disorders, psychopathology, Sniffin’ Sticks, odor threshold, odor identification, odor pleasantness

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