Back to Journals » OncoTargets and Therapy » Volume 10

Ocular basal cell carcinoma: a brief literature review of clinical diagnosis and treatment

Authors Shi Y, Jia R, Fan X

Received 15 December 2016

Accepted for publication 2 March 2017

Published 8 May 2017 Volume 2017:10 Pages 2483—2489


Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Akshita Wason

Peer reviewer comments 2

Editor who approved publication: Dr Chiung-Kuei Huang

Yingyun Shi, Renbing Jia, Xianqun Fan

Department of Ophthalmology, Shanghai Ninth People’s Hospital, Shanghai, People’s Republic of China

Abstract: Basal cell carcinoma (BCC) is a common malignant tumor throughout the world. One of the known risk factors of BCC is intense exposure to ultraviolet radiation. More than 50% of BCCs of the eyelid initially occur on the lower lid. The gold standard of diagnosis of BCC is histopathology. Treatment options for BCC consist of surgery, vismodegib, radiotherapy and imiquimod. Surgical excision using Mohs micrographic surgery or wide surgical excision with frozen section margin control is the first consideration for treatment of periocular BCC. Eyelid reconstruction should be carefully considered as both function and esthetic outcome in patients are important after clear excision of tumors. Exenteration is considered in the case of extensive orbital invasion or high-risk aggressive tumors in order to reduce the rate of recurrence.

Keywords: basal cell carcinoma, eyelid, orbit, surgery, vismodegib, radiotherapy, imiquimod

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]