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No associations between aromatase gene polymorphisms and breast cancer risk in Saudi patients

Authors Alanazi M, Alabdulkarim HA, Shaik J, Al Naeem A, Elrobh M, Al Amri A, Al-Mukaynizi F, Semlali A, Warsy A, Parine NR

Received 15 March 2015

Accepted for publication 28 May 2015

Published 3 September 2015 Volume 2015:8 Pages 2453—2459

DOI https://doi.org/10.2147/OTT.S84696

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 5

Editor who approved publication: Dr Faris Farassati


Mohammed Alanazi,1 Huda A Alabdulkarim,2 Jilani P Shaik,1 Abdulrahman Al Naeem,3 Mohammad Elrobh,1 Abdullah Al Amri,1 Fatimah Basil al-Mukaynizi,1 Abdelhabib Semlali,1 Arjumand Warsy,1 Narasimha Reddy Parine1

1Department of Biochemistry, College of Science, King Saud University, 2Comprehensive Cancer Center at King Fahad Medical City, 3Department of Women’s Imaging, King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia

Background: Cytochrome P450 (CYP)19A1 encodes aromatase, the enzyme responsible for the conversion of androgens to estrogens, and may play a role in variation in outcomes among women with breast cancer. The aim of this study was to analyze the genetic association of rs4646 (A > C) and rs700518 (Val > Val) in the CYP19A1 gene with the risk of breast cancer.
Methods: These two single nucleotide polymorphisms (SNPs) were analyzed in a primary study group of breast cancer patients and healthy control subjects. Genotypes were determined by the TaqMan SNP analysis technique. The study data were analyzed using the chi-square or t-test and logistic regression analysis by Statistical Package for the Social Sciences version 16 software.
Results: rs4646 and rs700518 had no association with susceptibility to breast cancer. There was no significant association for either of these SNPs overall in breast cancer samples when compared with healthy control samples. Our data do not support a relationship between the CYP19A1 rs4646 and rs700518 SNPs and risk of breast cancer. It may be that there are ethnic differences with regard to this relationship.
Conclusion: This study demonstrated that CYP19A1 rs4646 and rs700518 SNPs may not be involved in the etiology of breast cancer in the Saudi population. Confirmation of our findings in larger populations of other ethnicities could provide evidence for the role of the CYP19A1 gene in breast carcinomas.

Keywords: CYP19A1, rs4646, rs700518, breast cancer, genetic polymorphisms

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