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New insights from animal models of colon cancer: inflammation control as a new facet on the tumor suppressor APC gem

Authors Zeineldin M, Neufeld K

Received 25 November 2014

Accepted for publication 29 December 2014

Published 30 January 2015 Volume 2015:5 Pages 39—52

DOI https://doi.org/10.2147/GICTT.S51386

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Eileen O'Reilly


Maged Zeineldin, Kristi L Neufeld

Department of Molecular Biosciences, University of Kansas, Lawrence, KS, USA

Abstract: Colorectal cancer (CRC) is one of the most common causes of cancer-related deaths worldwide. As with other cancers, CRC is a genetic disease, however, several risk factors including diet and chronic colitis predispose to the disease. Mutations in the tumor suppressor adenomatous polyposis coli (APC) initiate most cases of CRC. Recent data from mouse models suggest that APC mutations and colitis are not completely independent factors in colorectal carcinogenesis. Here, we review the evidence supporting an interaction between APC mutations and chronic colitis. We will also discuss possible pathophysiologic mechanisms behind this interaction.

Keywords: rodent model, colon cancer, adenomatous polyposis coli, APC, tumor suppressor, inflammatory bowel disease
 

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