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New developments in the treatment of metastatic gastric cancer: focus on trastuzumab

Authors Rose JS, Bekaii-Saab T

Published 24 March 2011 Volume 2011:4 Pages 21—26


Review by Single anonymous peer review

Peer reviewer comments 2

Jeffrey S Rose, Tanios S Bekaii-Saab
Department of Internal Medicine, Division of Medical Oncology, The Ohio State University – Arthur James Cancer Hospital, Columbus, OH, USA

Abstract: Patients with metastatic gastric cancer have a poor outcome. The development of new combinations of chemotherapy has led to steady but only modest gains in overall survival with largest effects reported with two- and three-drug regimens. Trastuzumab, a fully humanized monoclonal antibody directed at the human epidermal growth factor receptor-2 (HER2), has been found to improve response rate and survival in patients with advanced gastric cancer. This update will review the role of HER2 and summarize therapeutic advances in the use of trastuzumab in advanced gastric cancer.

Keywords: gastric, gastroesophageal, adenocarcinoma, chemotherapy, trastuzumab

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