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New and emerging therapies for the treatment of rheumatoid arthritis

Authors Feely M

Published 28 July 2010 Volume 2010:2 Pages 35—43


Review by Single anonymous peer review

Peer reviewer comments 3

Michael G Feely
Division of Rheumatology and Immunology, Department of Internal Medicine, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, NE, USA

Abstract: The introduction of tumor necrosis factor (TNF) inhibitors in the late 1990s ­significantly changed the therapeutic approach for rheumatoid arthritis (RA). With the approval of subsequent TNF inhibitors as well as other biologic agents effective in the management of RA, the treatment paradigm has become increasingly complex. This review examines the current literature regarding the efficacy and toxicity of these and other new anti-rheumatic therapies and discusses effective therapeutic strategies for their use.

Keywords: biologics, tumor necrosis factor inhibitors, DMARDs, infliximab, etancercept, adalimumab, golimumab, certolizumab, abatacept, rituximab, tocilizumab

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