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Neutrophil/Lymphocyte Ratio as an Inflammatory Predictor of Dry Eye Disease: A Case-Control Study

Authors Meng YF, Pu Q, Ma Q, Zhu W, Li XY

Received 18 December 2020

Accepted for publication 5 March 2021

Published 23 March 2021 Volume 2021:17 Pages 259—266

DOI https://doi.org/10.2147/TCRM.S298156

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Professor Deyun Wang


Yi-Fang Meng,1,2,* Qi Pu,1,* Qian Ma,1 Wei Zhu,2 Xin-Yu Li1

1Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China; 2Department of Ophthalmology, Changshu No. 2 People’s Hospital, Changshu, Jiangsu, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Xin-Yu Li
Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, Hubei, 430030, People’s Republic of China
Tel/Fax +86-027-83663456
Email [email protected]
Wei Zhu
Department of Ophthalmology, Changshu No. 2 People’s Hospital, Changshu, Jiangsu, People’s Republic of China
Email [email protected]

Background: The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been used as indicators of inflammation, however, their roles in dry eye disease (DED) patients require advanced study
Materials and Methods: A total of 104 DED cases and 97 healthy controls from January 2020 to May 2020 were enrolled in this study. The dry eye related clinical variables, including Schirmer I test, tear break-up time (TBUT), corneal fluorescein staining (CFS) and Ocular Surface Disease Index (OSDI), were detected in all the participants. Besides, the NLR and PLR pattern in DED cases were detected and their potential value as inflammatory predictors of DED were evaluated. In advanced analyses, the correlation between NLR and DED severity was examined.
Results: The NLR and PLR were 2.59 ± 1.25 and 117.48 ± 54.68 in the DED group, respectively, while they were 2.20 ± 1.24 and 115.48 ± 54.33 in the control group, respectively. The NLR was higher in the DED group (p = 0.027), however, PLR was not significantly different compared with the control group (p = 0.951). In advanced analyses, it was found that more severe TBUT, CFS, and OSDI scores were detected in the high NLR group (NLR ≥ 2.145, p = 0.003, 0.013, and 0.017, respectively) compared with the low NLR group (NLR < 2.145).
Conclusion: The NLR value, but not PLR, of DED patients was higher than that of healthy controls. The NLR could be used as an inflammatory predictor to estimate the severity of DED.

Keywords: dry eye disease, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, case-control study, risk factor

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