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Neutrophil-to-lymphocyte ratio predicts the prognosis of stage II nasopharyngeal carcinoma

Authors Pan XB, Huang ST, Zhu XD

Received 24 April 2019

Accepted for publication 29 August 2019

Published 9 September 2019 Volume 2019:11 Pages 8269—8275

DOI https://doi.org/10.2147/CMAR.S213264

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Nicola Ludin

Peer reviewer comments 3

Editor who approved publication: Dr Teng


Xin-Bin Pan, Shi-Ting Huang, Xiao-Dong Zhu

Department of Radiation Oncology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi 530021, People’s Republic of China

Correspondence: Xiao-Dong Zhu
Department of Radiation Oncology, Affiliated Tumor Hospital of Guangxi Medical University, No.71 Hedi Road, Qingxiu District, Nanning, Guangxi 530021, People’s Republic of China
Tel +86 1 347 117 1468
Fax +86 0 771 531 2000
Email zhuxiaodonggx@163.com

Purpose: To assess the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) in stage II nasopharyngeal carcinoma (NPC).
Methods: Stage II (2010 UICC/AJCC staging system) NPC patients treated between January 2007 and December 2014 were retrospectively analyzed. The NLR was calculated from peripheral blood cell counts before treatment. The optimal cut-off value of NLR was determined by receiver operating characteristic curve analysis. Survival rates were compared according to the NLR value. Multivariable Cox regression analyses were performed to assess the association between the NLR and overall survival (OS), locoregional-free survival (LRFS), and distant metastasis-free survival (DMFS).
Results: Two hundred and fifty-one stage II NPC patients were included in this study. The NLR was correlated with T stage (r=0.158, p=0.012). An NLR ≥2.92 was associated with poor 5-year OS (84.3% vs 97.4%, p=0.001) and LRFS (91.4% vs 98.4%, p=0.003). An NLR ≥2.82 was associated with poor 5-year DMFS (92.6% vs 98.2%, p=0.033). The multivariate Cox regression analysis showed that an NLR ≥2.92 was an independent prognostic biomarker in stage II NPC.
Conclusion: The NLR is an independent prognostic factor in stage II NPC.

Keywords: nasopharyngeal carcinoma, NPC, stage II, neutrophil-to-lymphocyte ratio, NLR


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