Neuronavigation-guided high-dose repetitive transcranial magnetic stimulation for the treatment of depressive adolescents with suicidal ideation: a case series
Authors Pan F, Li D, Wang X, Lu S, Xu Y, Huang M
Received 2 June 2018
Accepted for publication 10 September 2018
Published 10 October 2018 Volume 2018:14 Pages 2675—2679
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Amy Norman
Peer reviewer comments 6
Editor who approved publication: Dr Yu-Ping Ning
Fen Pan,1,2 Da Li,1,2 Xiaojing Wang,3 Shaojia Lu,1,2 Yi Xu,1,2 Manli Huang1,2
1Department of Mental Health, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, People’s Republic of China; 2The Key Laboratory of Mental Disorder’s Management of Zhejiang Province, Hangzhou 310003, People’s Republic of China; 3School of Medicine, Zhejiang University, Hangzhou 310000, People’s Republic of China
Background: A high proportion of adolescents with major depressive disorder currently do not respond to conventional treatment. Repetitive transcranial magnetic stimulation (rTMS) is a promising treatment for major depressive disorder.
Case: We report on 3 cases of adolescents with suicidal ideation receiving 7 daily 10 Hz left prefrontal rTMS combined with pharmacotherapy treatment over 1 week for major depressive episode. The left dorsolateral prefrontal cortex was identified using magnetic resonance imaging-guided neuronavigation prior to stimulation. The suicidal ideation of these patients lessened significantly following rTMS treatment. Regarding adverse effects, symptoms of hypomania occurred in two patients since day 4, but no other side effects were found.
Conclusion: Neuronavigation-guided high-dose rTMS may be an effective and feasible treatment option for depressive adolescents with suicidal ideation. Caution over treatment-emergent mania/hypomania associated with rTMS is required.
Keywords: neuronavigation, repetitive transcranial magnetic stimulation, depressive adolescents, suicidal ideation
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