Neurogenic overactive bladder in spinal cord injury and multiple sclerosis: role of onabotulinumtoxinA
KD Ethans,1,2 AR Casey,1,2 RJ Bard,1,3 MP Namaka1
1University of Manitoba, 2Section of Physical Medicine and Rehabilitation, Health Sciences Centre, 3Section of Urology, Health Sciences Centre, Winnipeg, Manitoba, Canada
Abstract: People with neurogenic overactive bladder from either multiple sclerosis or spinal cord injury often suffer significant morbidity and decreased quality of life. Here we review the pathophysiology of neurogenic overactive bladder and the impact it can have on people with multiple sclerosis or spinal cord injury. We also address the various traditional treatment options and focus on the use of botulinum toxin A (specifically onabotulinumtoxinA) for this condition.
Keywords: neurogenic detrusor overactivity, overactive bladder, onabotulinumtoxinA, multiple sclerosis, spinal cord injury
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