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Neuroendocrine tumor of the common bile duct: a case report and review of the literature

Authors Liu Z, Zhang DY, Lu Z, Zhang P, Sun WL, Ma X, Wu H, Wu BQ, Zhou S

Received 18 January 2018

Accepted for publication 12 March 2018

Published 23 April 2018 Volume 2018:11 Pages 2295—2301


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Editor who approved publication: Dr Ingrid Espinoza

Zhong Liu,1 Deng-Yong Zhang,1 Zheng Lu,1 Pei Zhang,2 Wan-Liang Sun,1 Xiang Ma,1 Hua Wu,1 Bin-Quan Wu,1 Shuo Zhou1

1Department of General Surgery, The First Affiliated Hospital of Bengbu Medical College, Bengbu, People’s Republic of China; 2Department of Pharmacy, Bengbu Medical College, Bengbu, People’s Republic of China

We report a rare case of neuroendocrine tumor (NET) in the common bile duct (CBD). The patient is a 56-year-old female who presented to our department with symptoms of fever but without jaundice. A preoperative examination showed a tumor in the CBD. The tumor volume was almost 5.5 × 4.5 × 4 cm3, which is the biggest NET in the CBD reported on PubMed. The imaging results (computed tomography [CT] and magnetic resonance imaging [MRI]) were not consistent with CBD adenocarcinoma. The tumor appeared to oppress the growth of the CBD rather than originate in the bile duct wall; combined with the low blood bilirubin index and lack of jaundice symptoms, the preoperative diagnosis was not clear. We performed a radical resection of the cholangiocarcinoma. The patient recovered well before going home. The pathology was NET (Grade 2). The patient showed no recurrence to date, without intravenous chemotherapy (8 months).

Keywords: bile duct adenocarcinoma, neuroendocrine tumors, bile duct

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