Back to Journals » Cancer Management and Research » Volume 11

Natural gypenosides: targeting cancer through different molecular pathways

Authors Ahmad B, Khan S, Nabi G, Gamallat Y, Su P, Jamalat Y, Duan P, Yao L

Received 24 August 2018

Accepted for publication 8 February 2019

Published 27 March 2019 Volume 2019:11 Pages 2287—2297

DOI https://doi.org/10.2147/CMAR.S185232

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Andrew Yee

Peer reviewer comments 4

Editor who approved publication: Dr Rituraj Purohit


Bashir Ahmad,1,2 Suliman Khan,1,3,4 Ghulam Nabi,4,5 Yaser Gamallat,2 Pengyu Su,2 Yazeed Jamalat,2 Pengfei Duan,1,3 Lunguang Yao1,3

1Henan Provincial Engineering Research Center for Health Products of Livestock and Poultry, Nanyang Normal University, Nanyang, People’s Republic of China; 2College of Basic Medical Sciences, Dalian Medical University, Dalian City, People’s Republic of China; 3Collaborative Innovation Centre of Water Security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province/Key Laboratory of Ecological Security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province, School of Agricultural Engineering, Nanyang Normal University, Nanyang, People’s Republic of China; 4University of Chinese Academy of Sciences, Beijing, People’s Republic of China; 5Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei, People’s Republic of China

Abstract: The second foremost cause of mortality around the word is cancer. Conventional therapies, such as radiation, surgery, and chemotherapy have limited accessibility owing to secondary resistance. Therefore, convenient, safe, and nonresistant drugs are urgently needed. Plant-derived natural products have attracted considerable interest owing to their high efficacy, low toxicity, and convenience. Gypenosides (Gyp) inhibit invasion, migration, metastasis, and proliferation and induce apoptosis in different cancers, including oral, lung, colorectal, hepatocellular, and leukemic cancers through different molecular pathways. This review summarizes Gyp studies on cancer to serve as a reference for further research and clinical trials.

Keywords: cancer, surgery, chemotherapy, radiation therapy, Gyp, oral, lung, leukemic, colorectal, hepatocellular

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]