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Nanoscale 3D Bioprinting for Osseous Tissue Manufacturing

Authors Wang Y, Gao M, Wang D, Sun L, Webster TJ

Received 3 May 2018

Accepted for publication 6 November 2018

Published 14 January 2020 Volume 2020:15 Pages 215—226

DOI https://doi.org/10.2147/IJN.S172916

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Lei Yang


Yujia Wang, 1 Ming Gao, 1 Danquan Wang, 2 Linlin Sun, 1, 3 Thomas J Webster 1, 3

1Department of Chemical Engineering, Northeastern University, Boston, MA 02115, USA; 2Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA; 3Wenzhou Institute of Biomaterials and Engineering, Wenzhou Medical University, Wenzhou, Zhejiang 325001, People’s Republic of China

Correspondence: Linlin Sun; Thomas J Webster
Department of Chemical Engineering, Northeastern University, Boston, MA 02115, USA
Tel +1 6173732285; +1 6173736585
Fax +1 6173736585
Email l.sun@neu.edu; th.webster@neu.edu

Abstract: 3D printing, as a driving force of innovation over many areas, brings numerous manufacturing methods together from the macro to nano scales. New revolutionary materials (such as polymeric materials and natural biomaterials) can be produced into unique 3D printed nanostructures. The morphology and functionality of various 3D printing methods as well in vitro and in vivo results of their use towards regenerating bone are discussed in this review. This review further focuses nano scale 3D bioprinting technology for bone tissue engineering, mainly including recent progress in research on technical materials and methods, typical applications, and crucial achievements; explaining the scientific and technical challenges for bone tissue fabrication; and describing micro-nano scale 3D printing application prospects, development directions, and trends for the future for this field to realize its full potential.

Keywords: orthopedic, nanoparticles, nanotextured, bone, advance manufacturing
 

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